TY - JOUR
TI - Efficacy of Dietary Manipulations for Depleting Intrahepatic Triglyceride Content: Implications for the Management of Non-alcoholic Fatty Liver Disease
AU - Sandby, K.
AU - Geiker, N.R.W.
AU - Dalamaga, M.
AU - Grønbæk, H.
AU - Magkos, F.
JO - Current Obesity Reports
PY - 2021
VL - 10
TODO - 2
SP - 125-133
PB - Springer-Verlag
SN - 2162-4968
TODO - 10.1007/s13679-021-00430-4
TODO - adult;  alcohol consumption;  appetite;  bariatric surgery;  body mass;  caloric intake;  diet composition;  dietary fiber;  dietary intake;  energy balance;  female;  fermentation;  food intake;  glucose blood level;  glucose metabolism;  glycemic index;  glycemic load;  human;  insulin resistance;  insulin sensitivity;  intrahepatic triglyceride balance;  ketogenic diet;  lifestyle modification;  macronutrient;  male;  milk;  nonalcoholic fatty liver;  physical activity;  Review;  body weight loss;  diet;  energy metabolism;  fat intake;  liver;  metabolism;  nonalcoholic fatty liver, triacylglycerol, Diet;  Dietary Fats;  Energy Intake;  Energy Metabolism;  Humans;  Liver;  Non-alcoholic Fatty Liver Disease;  Nutrients;  Triglycerides;  Weight Loss
TODO - Purpose of Review: Understanding the effects of dietary manipulations on intrahepatic triglyceride (IHTG) balance will have important implications for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Recent Findings: Reducing calorie intake to induce weight loss is the most potent intervention to decrease IHTG. Carbohydrate restriction during the initial stages of weight loss may be particularly beneficial, but at later stages, the amount of weight loss predominates over diet composition. By contrast, during weight stability, restricting calories from fat seems to be optimal for depleting liver fat. The degree of dietary fat saturation and the glycemic index of the carbohydrate have inconsistent effects on IHTG. Recently, the matrix of some foods (e.g., dairy) has been inversely associated with NAFLD. Summary: Dietary macronutrients differ in their effects on liver fat depending on the energy balance and the matrix of the food in which they are consumed. Therefore, investigations into dietary approaches for managing NAFLD should shift their perspective from that of isolated nutrients to that of whole foods and diets and include useful mechanistic insights. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
ER -