TY - JOUR
TI - Unfractionated heparin reduces hepcidin levels in critically ill patients
AU - Vagionas, D.
AU - Politou, M.
AU - Kompoti, M.
AU - Papadakis, D.-D.
AU - Kostakou, E.
AU - Theodoulou, D.
AU - Kaniaris, E.
AU - Rovina, N.
AU - Koutsoukou, A.
AU - Vasileiadis, I.
JO - Internal Medicine Journal
PY - 2021
VL - 51
TODO - 5
SP - 797-801
PB - John Wiley and Sons Inc
SN - 1444-0903, 1445-5994
TODO - 10.1111/imj.15317
TODO - C reactive protein;  creatinine;  heparin;  hepcidin;  heparin;  hepcidin, aged;  APACHE;  Article;  biochemistry;  blood sampling;  chemiluminescence immunoassay;  chemiluminescent microparticle immunoassay;  chronic obstructive lung disease;  clinical article;  critically ill patient;  disease exacerbation;  dose response;  drug dose increase;  enzyme linked immunosorbent assay;  female;  heart failure;  heart infarction;  hospital admission;  hospitalization;  human;  intensive care unit;  limb ischemia;  male;  mortality;  non invasive procedure;  observational study;  polyserositis;  prospective study;  renal replacement therapy;  septic shock;  treatment duration;  anemia;  critical illness, Anemia;  Critical Illness;  Heparin;  Hepcidins;  Humans
TODO - A strong anti-hepcidin activity has been observed in heparins. Mean hepcidin levels were significantly reduced compared to baseline, following the first day of unfractionated heparin administration in critically patients. Heparin displayed a strong independent negative association with hepcidin. These results may lead to future treatment methods of forms of anaemia characterised by hepcidin excess, common among the critically ill. © 2021 Royal Australasian College of Physicians
ER -