TY - JOUR
TI - A Brief Review of Brain's Blood Flow-Metabolism Coupling and Pressure Autoregulation
AU - Papasilekas, T.
AU - Themistoklis, K.M.
AU - Melanis, K.
AU - Patrikelis, P.
AU - Spartalis, E.
AU - Korfias, S.
AU - Sakas, D.
JO - Journal of Neurological Surgery, Part A: Central European Neurosurgery
PY - 2021
VL - 82
TODO - 3
SP - 257-261
PB - Georg Thieme Verlag
SN - null
TODO - 10.1055/s-0040-1721682
TODO - arterial pressure;  autoregulation;  blood pressure regulation;  brain blood flow;  brain blood vessel;  brain metabolism;  brain perfusion;  cerebrovascular accident;  heart output;  human;  intracranial pressure;  neurovascular coupling;  parasympathetic nerve cell;  Review;  somatosensory system;  subarachnoid hemorrhage;  sympathetic nerve cell;  traumatic brain injury;  blood pressure;  brain;  brain circulation;  energy metabolism;  hemodynamics;  homeostasis;  metabolism;  physiology;  vascularization, Blood Pressure;  Brain;  Cerebrovascular Circulation;  Energy Metabolism;  Hemodynamics;  Homeostasis;  Humans
TODO - Background  The human brain, depending on aerobic glycolysis to cover its metabolic needs and having no energy reserves whatsoever, relies on a constant and closely regulated blood supply to maintain its structural and functional integrity. Cerebral autoregulation, that is, the brain's intrinsic ability to regulate its own blood flow independently from the systemic blood pressure and cardiac output, is an important physiological mechanism that offers protection from hypoperfusion injury. Discussion  Two major independent mechanisms are known to be involved in cerebral autoregulation: (1) flow-metabolism coupling and (2) myogenic responses of cerebral blood vessels to changes in transmural/arterial pressure. A third, less prominent component of cerebral autoregulation comes in the form of neurogenic influences on cerebral vasculature. Conclusion  Although fragmentation of cerebral autoregulation in separate and distinct from each other mechanisms is somewhat arbitrary, such a scheme is useful for reasons of simplification and to better understand their overall effect. Comprehension of cerebral autoregulation is imperative for clinicians in order for them to mitigate consequences of its impairment in the context of traumatic brain injury, subarachnoid hemorrhage, stroke, or other pathological conditions. © 2021. Thieme. All rights reserved.
ER -