TY - JOUR TI - Detection and Characterization of Musculoskeletal Cancer Using Whole-Body Magnetic Resonance Imaging AU - Isaac, A. AU - Lecouvet, F. AU - Dalili, D. AU - Fayad, L. AU - Pasoglou, V. AU - Papakonstantinou, O. AU - Ahlawat, S. AU - Messiou, C. AU - Weber, M.-A. AU - Padhani, A.R. JO - Seminars in Musculoskeletal Radiology PY - 2020 VL - 24 TODO - 6 SP - 726-749 PB - Thieme Medical Publishers Inc SN - 1089-7860, 1098-898X TODO - 10.1055/s-0040-1719018 TODO - Article; bone cancer; bone disease; bone tumor; cancer diagnosis; clinical assessment; diagnostic imaging; disease burden; dual energy computed tomography; dynamic contrast-enhanced magnetic resonance imaging; human; incidental finding; myeloproliferative disorder; myositis; peripheral nerve tumor; positron emission tomography; primary tumor; priority journal; qualitative analysis; quantitative analysis; vasculitis; whole body MRI; bone tumor; diagnostic imaging; muscle tumor; nuclear magnetic resonance imaging; pathology; procedures; soft tissue tumor; whole body imaging, Bone Neoplasms; Humans; Magnetic Resonance Imaging; Muscle Neoplasms; Soft Tissue Neoplasms; Whole Body Imaging TODO - Whole-body magnetic resonance imaging (WB-MRI) is gradually being integrated into clinical pathways for the detection, characterization, and staging of malignant tumors including those arising in the musculoskeletal (MSK) system. Although further developments and research are needed, it is now recognized that WB-MRI enables reliable, sensitive, and specific detection and quantification of disease burden, with clinical applications for a variety of disease types and a particular application for skeletal involvement. Advances in imaging techniques now allow the reliable incorporation of WB-MRI into clinical pathways, and guidelines recommending its use are emerging. This review assesses the benefits, clinical applications, limitations, and future capabilities of WB-MRI in the context of other next-generation imaging modalities, as a qualitative and quantitative tool for the detection and characterization of skeletal and soft tissue MSK malignancies. © 2020 BMJ Publishing Group. All rights reserved. ER -