TY - JOUR
TI - Prevalence, distribution and clinical significance of joints, muscles and bones in sarcoidosis: an 18F-FDG-PET/CT study
AU - Papiris, S.A.
AU - Manali, E.D.
AU - Papaioannou, A.I.
AU - Georgakopoulos, A.
AU - Kolilekas, L.
AU - Pianou, N.K.
AU - Kallergi, M.
AU - Papaporfyriou, A.
AU - Kallieri, M.
AU - Apollonatou, V.
AU - Papadaki, G.
AU - Malagari, K.
AU - Kelekis, N.L.
AU - Pneumatikos, S.G.
AU - Chatziioannou, S.
JO - Expert Review of Respiratory Medicine
PY - 2020
VL - 14
TODO - 9
SP - 957-964
PB - Taylor and Francis Ltd.
SN - 1747-6348, 1747-6356
TODO - 10.1080/17476348.2020.1775587
TODO - fluorodeoxyglucose f 18;  fluorodeoxyglucose f 18;  radiopharmaceutical agent, adult;  Article;  asymptomatic disease;  bone;  chronicity;  coughing;  diffusing capacity for carbon monoxide;  disease activity;  dyspnea;  fatigue;  female;  follow up;  forced expiratory volume;  forced vital capacity;  human;  human tissue;  hypercalciuria;  joint;  lower limb;  major clinical study;  male;  maximum standardized uptake value;  muscle;  muscle contraction;  osseous sarcoidosis;  positron emission tomography-computed tomography;  prevalence;  retrospective study;  systemic disease;  total lung capacity;  treatment response;  bone;  diagnostic imaging;  joint;  middle aged;  muscle;  pathology;  sarcoidosis, Adult;  Bone and Bones;  Female;  Fluorodeoxyglucose F18;  Humans;  Joints;  Male;  Middle Aged;  Muscles;  Positron Emission Tomography Computed Tomography;  Radiopharmaceuticals;  Sarcoidosis
TODO - Objectives: In Sarcoidosis joints-muscles-bones (JMBs) localizations are of the least common. 18F-FDG-PET/CT imaging revolutionized detection of JMBs involvement by adding metabolic activity information and allowing for a comprehensive, whole-body mapping of the disease. Aim and methods: This study investigated prevalence, distribution, and clinical significance of JMBs sarcoidosis in 195 consecutive patients that underwent 18F-FDG PET/CT examination. Results: Joint and bone involvement were encountered in 15% of patients with a mean of the maximum-standardized-uptake-value (SUVmax) of 6.1. Most common location was the axial skeleton. Hypercalciuria was significantly more frequent in patients with osseous involvement (p = 0.003). Muscle activity (SUVmax = 2.4) was encountered in 20% of the patients, most frequently in treatment-naïve (p = 0.02). The muscles of the lower extremities were affected the most. Muscle and bone localization coexist in 50% of the cases. JMBs disease was almost asymptomatic, not related to chronicity but to pulmonary, nodal, and systemic disease. Long-term follow-up and treatment response of affected patients confirmed sarcoidosis. Conclusion: 18F-FDG-PET/CT revealed JMBs localizations and coexistence with other organ sites supporting the concept that sarcoidosis is a systemic disease. By allowing an integrative interpretation of multi-organ involvement in the context of a pattern highly suggestive of sarcoidosis, it strongly keeps-off the diagnosis of malignancy. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
ER -