TY - JOUR
TI - Antigen-presenting cells in ocular surface diseases
AU - Kalogeropoulos, D.
AU - Papoudou-Bai, A.
AU - Lane, M.
AU - Goussia, A.
AU - Charchanti, A.
AU - Moschos, M.M.
AU - Kanavaros, P.
AU - Kalogeropoulos, C.
JO - International Ophthalmology
PY - 2020
VL - 40
TODO - 6
SP - 1603-1618
PB - Springer-Verlag
SN - 0165-5701
TODO - 10.1007/s10792-020-01329-0
TODO - antigen presenting cell;  cell function;  cell maturation;  dry eye;  eye allergy;  human;  Human alphaherpesvirus 1;  immunopathogenesis;  microbial keratitis;  nonhuman;  ocular surface disease;  pterygium;  Review;  antigen presenting cell;  cellular immunity;  immunology;  lacrimal fluid;  metabolism;  pathology, Antigen-Presenting Cells;  Dry Eye Syndromes;  Humans;  Immunity, Cellular;  Tears
TODO - Purpose: To review the role of antigen-presenting cells (APC) in the pathogenesis of ocular surface diseases (OSD). Methods: A thorough literature search was performed in PubMed database. An additional search was made in Google Scholar to complete the collected items. Results: APCs have the ability to initiate and direct immune responses and are found in most lymphoid and non-lymphoid tissues. APCs continuously sample their environment, present antigens to T cells and co-ordinate immune tolerance and responses. Many different types of APCs have been described and there is growing evidence that these cells are involved in the pathogenesis of OSD. OSD is a complex term for a myriad of disorders that are often characterized by ocular surface inflammation, tear film instability and impairment of vision. Conclusions: This review summarizes the current knowledge concerning the immunotopographical distribution of APCs in the normal ocular surface. APCs appear to play a critical role in the pathology of a number of conditions associated with OSD including infectious keratitis, ocular allergy, dry eye disease and pterygium. © 2020, Springer Nature B.V.
ER -