TY - JOUR TI - Intrahepatic cholangiocarcinoma: Limitations for resectability, current surgical concepts and future perspectives AU - Machairas, N. AU - Lang, H. AU - Jayant, K. AU - Raptis, D.A. AU - Sotiropoulos, G.C. JO - European Journal of Surgical Oncology PY - 2020 VL - 46 TODO - 5 SP - 740-746 PB - W.B. Saunders Ltd SN - 0748-7983 TODO - 10.1016/j.ejso.2020.01.028 TODO - bile duct carcinoma; cancer adjuvant therapy; cancer recurrence; cancer surgery; follow up; futurology; human; liver preservation; liver resection; liver transplantation; lymph node dissection; lymph node metastasis; macrovascular invasion; minimally invasive surgery; neoadjuvant therapy; priority journal; reoperation; Review; treatment outcome; tumor invasion; bile duct cancer; bile duct carcinoma; blood vessel; intrahepatic bile duct; laparoscopy; liver failure; multiple cancer; pathology; postoperative complication; procedures; surgical margin; tumor recurrence, Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Blood Vessels; Cholangiocarcinoma; Hepatectomy; Hepatic Insufficiency; Humans; Laparoscopy; Liver Transplantation; Lymph Node Excision; Margins of Excision; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Postoperative Complications TODO - Intrahepatic cholangiocarcinoma (iCCA) is the second most common hepatic malignancy and its incidence has been shown to increase significantly during the past decades. Complete surgical resection is currently acknowledged as the only curative treatment option able to provide adequate long-term outcomes. We herein review technical, functional and oncologic limitations for resectability, discuss current surgical aspects as well as highlight the fields in which future research and practice should focus on in order to ameliorate long-term outcomes in patients with iCCA. © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology ER -