TY - JOUR
TI - Paraneoplastic Pemphigus Associated with Bilateral Corneal Perforations in Follicular Dendritic Cell Sarcoma
AU - Venkateswaran, N.
AU - Klavdianou, O.
AU - Kondylis, G.
AU - Kosmidis, I.
AU - Palioura, S.
JO - Ocular Immunology and Inflammation
PY - 2020
VL - null
TODO - null
SP - null
PB - Taylor and Francis Ltd.
SN - 0927-3948, 1744-5078
TODO - 10.1080/09273948.2020.1828491
TODO - null
TODO - Purpose: To describe a case of paraneoplastic pemphigus (PNP) presenting as spontaneous bilateral corneal perforations in a patient with follicular dendritic cell sarcoma. Methods: Retrospective chart review Results: A 73-year-old Greek woman with a history of follicular dendritic cell sarcoma (FDCS) presented with bilateral corneal perforations and a cicatrizing conjunctivitis. Her diagnosis was consistent with PNP with corneal and conjunctival involvement after a change in her chemotherapy regimen from intravenous cyclophosphamide to gemcitabine. She was treated with a multilayered amniotic membrane in the right eye and cyanoacrylate glue in the left eye. Systemic intravenous cyclophosphamide and oral prednisone were re-started. Both perforations healed but the patient passed away soon after precluding further follow-up. Conclusions: Ocular manifestations of PNP can rarely present with spontaneous corneal perforations. This is the first case of FDCS-associated PNP with corneal involvement. Such cases should be diagnosed expediently and managed with aggressive systemic immunosuppressive therapy. © 2020 Taylor & Francis Group, LLC.
ER -