TY - JOUR TI - Depression as mediator and or moderator on the relationship between hopelessness and patients’ desire for hastened death AU - Parpa, E. AU - Tsilika, E. AU - Galanos, A. AU - Nikoloudi, M. AU - Mystakidou, K. JO - Supportive Care in Cancer PY - 2019 VL - 27 TODO - 11 SP - 4353-4358 PB - Springer-Verlag SN - 0941-4355, 1433-7339 TODO - 10.1007/s00520-019-04715-2 TODO - adult; advanced cancer; aged; Article; Beck Depression Inventory; Beck Hopelessness Scale; bootstrapping; cancer palliative therapy; death; depression; female; Greece; hopelessness; human; major clinical study; male; metastasis; patient attitude; priority journal; attitude to death; depression; middle aged; psychology; very elderly, Adult; Aged; Aged, 80 and over; Attitude to Death; Depression; Female; Humans; Male; Middle Aged TODO - Purpose: Previous findings have shown that depression in advanced stages of cancer is associated with hopelessness and frequently with wishes for hastened death. The current study tries to investigate the relationship between hopelessness and desire for hastened death and if depression may be a moderator and/or mediator role in patients with advanced cancer. Method: The participants were 102 patients with advanced cancer which they completed the Beck Hopelessness Scale (BHS), the Greek Schedule of Attitudes towards Hastened Death (G-SAHD), and the Greek Beck Depression Inventory (BDI). Results: Depression was highly correlated with hopelessness and desire for hastened death. Mediation analyses revealed that hopelessness influenced desire for hastened death as well as indirectly by its effect on depression. Similarly, depression was found as moderator in the relationship between hopelessness with desire for hastened death. Conclusions: Hopelessness and desire for hastened death in patients with advanced cancer should be diagnosed and treated by taking into consideration the optimum care of depression as a priority in palliative care. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. ER -