TY - JOUR
TI - Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines
AU - Hong, C.H.L.
AU - Gueiros, L.A.
AU - Fulton, J.S.
AU - Cheng, K.K.F.
AU - Kandwal, A.
AU - Galiti, D.
AU - Fall-Dickson, J.M.
AU - Johansen, J.
AU - Ameringer, S.
AU - Kataoka, T.
AU - Weikel, D.
AU - Eilers, J.
AU - Ranna, V.
AU - Vaddi, A.
AU - Lalla, R.V.
AU - Bossi, P.
AU - Elad, S.
AU - On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO)
JO - Supportive Care in Cancer
PY - 2019
VL - 27
TODO - 10
SP - 3949-3967
PB - Springer-Verlag
SN - 0941-4355, 1433-7339
TODO - 10.1007/s00520-019-04848-4
TODO - bicarbonate;  chlorhexidine;  sodium chloride, Article;  cancer chemotherapy;  cancer patient;  cancer radiotherapy;  dental procedure;  head and neck cancer;  hematopoietic stem cell transplantation;  human;  meta analysis;  mouth hygiene;  oral mucositis;  patient education;  practice guideline;  priority journal;  systematic review;  methodology;  mucosa inflammation;  neoplasm;  oncology;  procedures;  stomatitis, Dental Care;  Humans;  Medical Oncology;  Mucositis;  Neoplasms;  Practice Guidelines as Topic;  Research Design;  Stomatitis
TODO - Purpose: The aim of this study was to update the clinical practice guidelines for the use of basic oral care (BOC) interventions for the prevention and/or treatment of oral mucositis (OM). Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention in each cancer treatment setting was assigned an evidence level. The findings were added to the database used to develop the 2013 MASCC/ISOO clinical practice guidelines. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible. Results: A total of 17 new papers across six interventions were examined and merged with a previous database. Based on the literature, the following guidelines were possible. The panel suggests that the implementation of multi-agent combination oral care protocols is beneficial for the prevention of OM during chemotherapy, head and neck (H&N) radiation therapy (RT), and hematopoietic stem cell transplantation (Level of Evidence III). The panel suggests that chlorhexidine not be used to prevent OM in patients undergoing H&N RT (Level of Evidence III). No guideline was possible for professional oral care, patient education, saline, and sodium bicarbonate, and expert opinion complemented these guidelines. Conclusions: The evidence supports the use of multi-agent combination oral care protocols in the specific populations listed above. Additional well-designed research is needed on the other BOC interventions prior to guideline formulation. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
ER -