TY - JOUR
TI - Impact of renin–angiotensin–aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters
AU - Angelidis, G.
AU - Samara, M.
AU - Papathanassiou, M.
AU - Satra, M.
AU - Valotassiou, V.
AU - Tsougos, I.
AU - Psimadas, D.
AU - Tzavara, C.
AU - Alexiou, S.
AU - Koutsikos, J.
AU - Demakopoulos, N.
AU - Giamouzis, G.
AU - Triposkiadis, F.
AU - Skoularigis, J.
AU - Kollia, P.
AU - Georgoulias, P.
JO - Journal of Nuclear Cardiology
PY - 2019
VL - 26
TODO - 4
SP - 1298-1308
PB - Springer New York LLC
SN - 1071-3581, 1532-6551
TODO - 10.1007/s12350-017-1181-8
TODO - angiotensin 1 receptor;  angiotensin 2 receptor;  angiotensinogen;  beta adrenergic receptor blocking agent;  calcium channel blocking agent;  dipeptidyl carboxypeptidase;  genomic DNA;  nitric acid derivative;  renin;  tetrofosmin tc 99m;  angiotensin receptor;  angiotensinogen;  dipeptidyl carboxypeptidase;  renin, a1166c gene;  adult;  aged;  allele;  Article;  c3123a gene;  c5312t gene;  cardiovascular parameters;  cardiovascular risk;  coronary artery disease;  diabetes mellitus;  DNA polymorphism;  female;  gated single photon emission computed tomography;  gene;  heart left ventricle enddiastolic volume;  heart left ventricle endsystolic volume;  heart muscle perfusion;  heterozygote;  homozygote;  human;  hyperlipidemia;  hypertension;  indel mutation;  lung heart ratio;  m235t gene;  major clinical study;  male;  myocardial perfusion imaging;  obesity;  priority journal;  renin angiotensin aldosterone system;  scoring system;  summed difference score;  summed rest score;  summed stress score;  t174m gene;  thorax pain;  transient ischemic dilation;  coronary artery blood flow;  diagnostic imaging;  genetic polymorphism;  genetics;  middle aged;  myocardial perfusion imaging;  pathophysiology;  renin angiotensin aldosterone system;  single photon emission computed tomography;  very elderly, Adult;  Aged;  Aged, 80 and over;  Angiotensinogen;  Coronary Artery Disease;  Coronary Circulation;  Female;  Humans;  Male;  Middle Aged;  Myocardial Perfusion Imaging;  Peptidyl-Dipeptidase A;  Polymorphism, Genetic;  Receptors, Angiotensin;  Renin;  Renin-Angiotensin System;  Tomography, Emission-Computed, Single-Photon
TODO - Background: Renin–angiotensin–aldosterone system (RAAS) has an important role in atherosclerosis. We investigated the effects of six RAAS gene polymorphisms on myocardial perfusion. Methods and Results: We examined 810 patients with known or suspected coronary artery disease (CAD) using stress–rest myocardial single-photon emission computed tomography. Summed stress score (SSS), summed rest score (SRS), summed difference score (SDS), transient ischemic dilation (TID), and lung/heart ratio (LHR) were recorded. The following gene polymorphisms were investigated: angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensinogen (AGT) M235T and T174M, angiotensin II type 1 receptor (AT1R) A1166C, renin (REN) C5312T, and angiotensin II type 2 receptor (AT2R) C3123A. The heterozygotes or homozygotes on ACE D allele were 7.54 times more likely to have abnormal SSS, while the AGT (T174M) heterozygotes were 5.19 times more likely to have abnormal SSS. The homozygotes of ACE D had significantly higher values on TID and LHR, while the AGT (T174M) heterozygotes had higher values on TID. The AT1R heterozygotes had greater odds for having SSS ≥ 3. The patients carried AT1R homozygosity of C allele had significantly higher values on TID, while heterozygotes of AT1R had significantly higher values on LHR. Conclusions: Among the polymorphisms investigated, ACE D allele had the strongest association with abnormal myocardial perfusion. © 2018, American Society of Nuclear Cardiology.
ER -