TY - JOUR
TI - International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV
AU - Singer, S.
AU - Amdal, C.D.
AU - Hammerlid, E.
AU - Tomaszewska, I.M.
AU - Castro Silva, J.
AU - Mehanna, H.
AU - Santos, M.
AU - Inhestern, J.
AU - Brannan, C.
AU - Yarom, N.
AU - Fullerton, A.
AU - Pinto, M.
AU - Arraras, J.I.
AU - Kiyota, N.
AU - Bonomo, P.
AU - Sherman, A.C.
AU - Baumann, I.
AU - Galalae, R.
AU - Fernandez Gonzalez, L.
AU - Nicolatou-Galitis, O.
AU - Abdel-Hafeez, Z.
AU - Raber-Durlacher, J.
AU - Schmalz, C.
AU - Zotti, P.
AU - Boehm, A.
AU - Hofmeister, D.
AU - Krejovic Trivic, S.
AU - Loo, S.
AU - Chie, W.-C.
AU - Bjordal, K.
AU - Brokstad Herlofson, B.
AU - Grégoire, V.
AU - Licitra, L.
AU - on behalf of the EORTC Quality of Life
AU - the EORTC Head
AU - Neck Cancer Groups
JO - Head and Neck Oncology
PY - 2019
VL - 41
TODO - 6
SP - 1725-1737
PB - John Wiley and Sons Inc
SN - null
TODO - 10.1002/hed.25609
TODO - aged;  clinical trial;  complication;  Europe;  female;  head and neck tumor;  human;  male;  middle aged;  multimodality cancer therapy;  phase 4 clinical trial;  prospective study;  psychology;  psychometry;  quality of life;  questionnaire;  reproducibility;  sensitivity and specificity;  very elderly, Aged;  Aged, 80 and over;  Combined Modality Therapy;  Europe;  Female;  Head and Neck Neoplasms;  Humans;  Male;  Middle Aged;  Outcome Assessment, Health Care;  Prospective Studies;  Psychometrics;  Quality of Life;  Reproducibility of Results;  Sensitivity and Specificity;  Surveys and Questionnaires
TODO - Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales. Conclusions: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life. © 2019 Wiley Periodicals, Inc.
ER -