TY - JOUR
TI - Meta-analysis of risk factors and complications associated with atrial fibrillation after oesophagectomy
AU - Schizas, D.
AU - Kosmopoulos, M.
AU - Giannopoulos, S.
AU - Giannopoulos, S.
AU - Kokkinidis, D.G.
AU - Karampetsou, N.
AU - Papanastasiou, C.A.
AU - Rouvelas, I.
AU - Liakakos, T.
JO - The British journal of surgery
PY - 2019
VL - 106
TODO - 5
SP - 534-547
PB - John Wiley and Sons Ltd
SN - null
TODO - 10.1002/bjs.11128
TODO - anastomosis leakage;  atrial fibrillation;  cancer staging;  coronary artery disease;  esophagus resection;  human;  hypertension;  incidence;  laparoscopy;  meta analysis;  outcome assessment;  pneumonia;  postoperative complication;  practice guideline;  priority journal;  Review;  risk assessment;  risk factor;  surgical mortality;  systematic review;  thoracoscopy;  adverse event;  anastomosis leakage;  atrial fibrillation;  complication;  esophagus resection;  esophagus tumor;  mortality;  pneumonia;  postoperative complication;  risk factor, Anastomotic Leak;  Atrial Fibrillation;  Coronary Artery Disease;  Esophageal Neoplasms;  Esophagectomy;  Humans;  Hypertension;  Pneumonia;  Postoperative Complications;  Risk Factors
TODO - Background: Oesophagectomy is associated with high morbidity and mortality rates. New-onset atrial fibrillation (AF) is a frequent complication following oesophagectomy. Several studies have explored whether new-onset AF is associated with adverse events after oesophagectomy. Methods: This review was performed according to PRISMA guidelines. Eligible studies were identified through a search of PubMed, Scopus and Cochrane CENTRAL databases up to 25 November 2018. A meta-analysis was conducted with the use of random-effects modelling. The I2 statistic was used to assess for heterogeneity. Results: In total, 53 studies including 9087 patients were eligible for analysis. The overall incidence of postoperative AF was 16·5 per cent. Coronary artery disease and hypertension were associated with AF, whereas diabetes, smoking and chronic obstructive pulmonary disease were not. Patients with AF had a significantly higher risk of overall postoperative adverse events than those without fibrillation (odds ratio (OR) 5·50, 95 per cent c.i. 3·51 to 8·30), including 30-day mortality (OR 2·49, 1·70 to 3·64), anastomotic leak (OR 2·65, 1·53 to 4·59) and pneumonia (OR 3·42, 2·39 to 4·90). Conclusion: Postoperative AF is frequently observed in patients undergoing oesophagectomy for cancer. It is associated with an increased risk of death and postoperative complications. © 2019 BJS Society Ltd Published by John Wiley & Sons Ltd
ER -