TY - JOUR
TI - Changes in serum leptin levels as well as sICAM-1 and sVCAM-1 soluble adhesion molecules during carotid endarterectomy
AU - Makris, S.
AU - Venetsanou, K.
AU - Spartalis, E.
AU - Kontogiannis, C.
AU - Georgiopoulos, G.
AU - Spartalis, M.
AU - Tsilimigras, D.I.
AU - Moris, D.
AU - Kakisis, I.
AU - Karaolanis, G.
AU - Patelis, N.
AU - Zymvragoudakis, V.
AU - Papasilekas, T.I.
AU - Themistoklis, K.M.
AU - Lazaris, A.
JO - European Review for Medical and Pharmacological Sciences
PY - 2019
VL - 23
TODO - 5
SP - 2257-2262
PB - Verduci Editore s.r.l
SN - 1128-3602, 2284-0729
TODO - 10.26355/eurrev_201903_17274
TODO - intercellular adhesion molecule 1;  leptin;  vascular cell adhesion molecule 1;  ICAM1 protein, human;  intercellular adhesion molecule 1;  LEP protein, human;  leptin;  vascular cell adhesion molecule 1, aged;  Article;  carotid atherosclerosis;  carotid endarterectomy;  cellular parameters;  clinical article;  clinical outcome;  clinical trial;  controlled study;  disease marker;  female;  hormone blood level;  human;  inflammation;  intercellular adhesion molecule 1 blood level;  internal carotid artery occlusion;  leptin blood level;  male;  outcome assessment;  oxidative stress;  postoperative period;  prospective study;  protein blood level;  protein determination;  vascular cell adhesion molecule 1 blood level;  blood;  carotid artery obstruction;  carotid endarterectomy;  case control study;  gene expression regulation;  middle aged;  procedures, Aged;  Carotid Stenosis;  Case-Control Studies;  Endarterectomy, Carotid;  Female;  Gene Expression Regulation;  Humans;  Intercellular Adhesion Molecule-1;  Leptin;  Male;  Middle Aged;  Oxidative Stress;  Prospective Studies;  Vascular Cell Adhesion Molecule-1
TODO - OBJECTIVE: Leptin is an adi-pokine, known to be associated with oxidative stress, inflammation, and atherogenesis. Leptin plays an essential role in atheromatosis-associated inflammatory cascade through stimulation of inflammatory mediators such as soluble intracellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sV-CAM-1). However, little is known about this association in patients with atherosclerosis and severe internal carotid artery (ICA) stenosis undergoing carotid endarterectomy (CEA). Our objective was to evaluate the variations of serum leptin levels, as well as sICAM-1 and sVCAM-1 levels in these patients during the process of CEA and 24 hours postoperatively. PATIENTS AND METHODS: The study group enrolled 50 patients undergoing CEA for ICA stenosis (> 70%). Serum leptin, sICAM-1 and sVCAM-1 plasma concentration measurements were performed at 4 distinct time points: before clamping of the ICA, 30 minutes after clamping of the ICA, 60 minutes after declamping of ICA and 24 hours postoperatively. RESULTS: Leptin was significantly decreased during CEA, but an overshooting in its levels was observed at 24 hours after the operation. Both sICAM-1 and sVCAM-1 initially followed the pattern of leptin changes but after completing CEA and up to 24 hours postoperatively a steep increase in their levels was not established. sV-CAM-1 and sICAM-1 correlated with indices of oxidative stress at peak inflammatory burden. CONCLUSIONS: Leptin is a circulating marker of carotid atherosclerosis. Oxidative stress and expression of sVCAM-1 and sICAM-1 on vascular endothelial cells are key features in the pathophysiological process of atherosclerosis. © 2019 Verduci Editore s.r.l. All Rights Reserved.
ER -