TY - JOUR
TI - The effect of bronchodilation and spirometry on fractional exhaled nitric oxide (FeNO50), bronchial NO flux (JawNO) and alveolar NO concentration (CANO) in children and young adults
AU - Karampitsakos, T.
AU - Protopapas, A.
AU - Gianoloudi, M.
AU - Papadopoulos, V.P.
AU - Bouros, D.
AU - Chatzimichael, A.
AU - Paraskakis, E.
JO - Journal of Asthma
PY - 2018
VL - 55
TODO - 8
SP - 882-889
PB - Taylor and Francis Ltd.
SN - 0277-0903, 1532-4303
TODO - 10.1080/02770903.2017.1373807
TODO - nitric oxide;  bronchodilating agent;  nitric oxide, adolescent;  adult;  Article;  asthma;  bronchodilatation;  bronchus;  child;  clinical article;  controlled study;  female;  forced expiratory volume;  forced vital capacity;  fractional exhaled nitric oxide;  human;  lung alveolus;  male;  spirometry;  young adult;  asthma;  breath analysis;  bronchus;  drug effect;  exhalation;  lung;  normal human;  pathophysiology;  procedures;  spirometry, Adolescent;  Adult;  Asthma;  Breath Tests;  Bronchi;  Bronchodilator Agents;  Child;  Exhalation;  Female;  Healthy Volunteers;  Humans;  Lung;  Male;  Nitric Oxide;  Spirometry;  Young Adult
TODO - Objective: Fractional exhaled nitric oxide (FeNO), bronchial nitric oxide (JawNO) and alveoar nitric oxide (CANO) are biomarkers of eosinophilic inflammation, usually measured simultaneously with spirometry and bronchodilation. Our aim was to investigate the effect of bronchodilation and spirometry on FeNO, CANO and JawNO in children and young adults with well-controlled asthma and in healthy volunteers. Methods: FeNO was measured in 95 subjects (62 controls, 33 asthmatics). CANO and JawNO were assessed in 41 of the subjects (35 healthy, 6 asthmatics.) Measurements were performed before spirometry (1), right after spirometry (2), 20 min after the first spirometry and bronchodilation (3), right after the post-bronchodilation spirometry (4) and 30 min after the last spirometry (5). Results: The presence of well-controlled asthma was not associated with different pattern of reaction after spirometry and bronchodilation. A statistically significant difference was observed only between FeNO4 and FeNO5, as well as between CANO1 and CANO3 (19.14 ± 1.68 vs 20.62 ± 1.85 ppb, p = 0.001 and 4.42 ± 0.40 vs 3.09±0.32 ppb, p = 0.001, respectively). Conclusions: Spirometry and bronchodilation have an insignificant effect on FeNO and JawNO. Even if a slight change occurs in FeNO and JawNO, this does not modify clinician's decision and therapeutic strategy. CANO values (CANO1) are significantly decreased 20 min after spirometry and bronchodilation. © 2017, © 2017 Taylor & Francis Group, LLC.
ER -