TY - JOUR
TI - A Novel Experimental Model of Colorectal Endometriosis
AU - Prodromidou, A.
AU - Pergialiotis, V.
AU - Pavlakis, K.
AU - Korou, L.M.
AU - Frountzas, M.
AU - Dimitroulis, D.
AU - Vaos, G.
AU - Perrea, D.N.
JO - Journal of Investigative Surgery
PY - 2018
VL - 31
TODO - 4
SP - 275-281
PB - Taylor and Francis Ltd.
SN - 0894-1939, 1521-0553
TODO - 10.1080/08941939.2017.1317374
TODO - cytokeratin 7, adult;  animal euthanasia;  animal experiment;  animal model;  animal tissue;  Article;  clinical evaluation;  colorectal disease;  colorectal endometriosis;  controlled study;  endometriosis;  female;  histopathology;  intestine tissue;  microscopy;  nonhuman;  peritoneal cavity;  priority journal;  rat;  Sprague Dawley rat;  uterus horn;  uterus surgery;  animal;  colon disease;  disease model;  endometriosis;  endometrium;  feasibility study;  human;  pathology;  rat;  rectum;  transplantation, Animals;  Colonic Diseases;  Disease Models, Animal;  Endometriosis;  Endometrium;  Feasibility Studies;  Female;  Humans;  Rats;  Rats, Sprague-Dawley;  Rectum
TODO - Purpose: Endometriosis is a disease that affects 6–10% of the female population, mainly women of reproductive age, and causes a variety of cyclic symptoms. Deep infiltrating endometriosis and in particular bowel involvement presents a challenge for modern surgery. To date, there are no experimental animal models in this field, demonstrating experimental induction of endometriosis directly attached to surface of the colon imitating human colorectal endometriosis; hence, the implementation of novel pharmaceutical and surgical strategies for the management of colorectal endometriosis is mainly limited to clinical studies. Aim of the study: To investigate whether induction of colorectal endometriotic lesions in is feasible in rats. Materials and Methods: Twenty, female, adult, non-pregnant Sprague Dawley rats sustained uterine horn resection, which was then placed around the rectum of the rat with the endometrial surface in direct contact with the bowel serosa and approximated in the serosal surface of the colon with two sutures. Results: Two weeks following, surgery rats were euthanized and the bowel was surgically explored. The presence of a cystic lump at the site of the surgical intervention was evaluated macroscopically and microscopically. Histopathology documented the presence of cystic endometriosis. The endometriotic focus was adherent to the bowel wall by large fibrous nodules with concomitant replacement of part of the outer longitudinal muscle layer. Conclusions: The findings of our study support that the proposed experimental model of colorectal endometriosis is feasible, easily reproducible and may be implemented in future research in this field. Copyright © 2018 Taylor & Francis Group, LLC.
ER -