TY - JOUR
TI - Mean platelet volume values in preeclampsia: A systematic review and meta-analysis
AU - Bellos, I.
AU - Fitrou, G.
AU - Pergialiotis, V.
AU - Papantoniou, N.
AU - Daskalakis, G.
JO - Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health
PY - 2018
VL - 13
TODO - null
SP - 174-180
PB - Elsevier B.V.
SN - 2210-7789
TODO - 10.1016/j.preghy.2018.06.016
TODO - anticoagulant agent;  hemoglobin, body mass;  disease severity;  gestational age;  hematocrit;  human;  maternal age;  mean platelet volume;  outcome assessment;  platelet count;  preeclampsia;  pregnant woman;  priority journal;  quantitative analysis;  regression analysis;  Review;  sample size;  scoring system;  second trimester pregnancy;  sensitivity analysis;  systematic review;  third trimester pregnancy;  univariate analysis;  blood;  blood pressure;  female;  meta analysis;  pathology;  pathophysiology;  predictive value;  preeclampsia;  pregnancy;  prognosis;  risk factor;  thrombocyte;  thrombocyte activation, Blood Platelets;  Blood Pressure;  Female;  Humans;  Mean Platelet Volume;  Platelet Activation;  Pre-Eclampsia;  Predictive Value of Tests;  Pregnancy;  Prognosis;  Risk Factors
TODO - Objective: Mean platelet volume (MPV) has been explored in several observational studies in the field of preeclampsia and current evidence seem to be conflicting. The purpose of the present meta-analysis is to evaluate the reported MPV differences in patients that develop preeclampsia and to compare them to those of otherwise healthy women. Design and methods: We searched the international literature using the Medline (1966–2018), Scopus (2004–2018), EMBASE (1947–2018) and Clinicaltrials.gov (2008–2018) databases. Statistical meta-analysis was performed using the RevMan 5.3 software. Results: The meta-analysis was based on outcomes reported from 50 studies that included 14,614 women. MPV was significantly higher in preeclamptic than healthy pregnant women (7905 women, MD: 1.04 fl, 95% CI [0.76, 1.32]). The mean difference was less evident among women with mild preeclampsia (6604 women, MD: 0.65 fl, 95% CI [0.19, 1.11]), compared to the severe ones (6119 women, MD: 1.28 fl, 95% CI [0.75, 1.80]). The results of the univariate meta-regression analysis showed that region, sample size, time to analysis, anticoagulant, platelet count and NOS score did not affect the outcomes of the meta-analysis. Conclusions: The findings of our meta-analysis suggest that mean platelet volume represents a promising biomarker for the detection and follow-up of patients that develop preeclampsia. However, given that the available evidence is drawn from case-control studies, future cohorts are needed in this field to accurately determine optimal timing and cut-off values that may be used in the clinical setting. © 2018 International Society for the Study of Hypertension in Pregnancy
ER -