TY - JOUR
TI - PlGF and sFlt-1 levels in patients with non-transfusion-dependent thalassemia: Correlations with markers of iron burden and endothelial dysfunction
AU - Kelaidi, C.
AU - Kattamis, A.
AU - Apostolakou, F.
AU - Poziopoulos, C.
AU - Lazaropoulou, C.
AU - Delaporta, P.
AU - Kanavaki, I.
AU - Papassotiriou, I.
JO - European Journal of Haematology
PY - 2018
VL - 100
TODO - 6
SP - 630-635
PB - Wiley-Blackwell Publishing Ltd
SN - 0902-4441, 1600-0609
TODO - 10.1111/ejh.13061
TODO - C reactive protein;  endothelin 1;  ferritin;  hemoglobin;  hemoglobin F;  hydroxyurea;  iron;  lactate dehydrogenase;  placental growth factor;  vasculotropin receptor 1;  von Willebrand factor;  biological marker;  FLT1 protein, human;  iron;  membrane protein;  PIGF protein, human;  vasculotropin receptor 1, adult;  angiogenesis;  Article;  beta thalassemia;  clinical article;  comorbidity;  controlled study;  disease association;  endothelial dysfunction;  erythrocyte;  erythropoiesis;  female;  ferritin blood level;  genotype;  hemoglobin blood level;  human;  hypoxemia;  immunoturbidimetry;  iron chelation;  iron overload;  lactate dehydrogenase blood level;  male;  non transfusion dependent thalassemia;  non transfusion dependent thalassemia;  oxidative stress;  priority journal;  pulmonary hypertension;  thalassemia;  adolescent;  blood;  metabolism;  middle aged;  sensitivity and specificity;  thalassemia;  vascular endothelium;  young adult, Adolescent;  Adult;  Biomarkers;  Endothelium, Vascular;  Female;  Humans;  Iron;  Male;  Membrane Proteins;  Middle Aged;  Sensitivity and Specificity;  Thalassemia;  Vascular Endothelial Growth Factor Receptor-1;  Young Adult
TODO - Background: Levels of the angiogenic cytokines placental growth factor (PlGF) and soluble Fms-like tyrosine kinase-1 (sFlt-1) and the angiogenic balance, expressed by sFlt-1/PlGF ratio, are perturbed in sickle-cell disease and iron overload, but they have not been evaluated in non-transfusion-dependent thalassemia (NTDT). Patients and Methods: We measured levels of PlGF, sFlt-1 and vWF:antigen in patients with NTDT of beta-thalassemia genotype, and correlated them with erythrocytic indices and markers of iron overload, inflammation, and tissue hypoxia. Thirty-four NTDT patients with mean hemoglobin level of 8.4 g/dL were included in the study along with 20 apparently healthy individuals who served as controls. Results: Ferritin, LDH, and hs-CRP were higher in patients as compared to controls. We found significant differences between patients and controls in regard to levels of PlGF (52.2 vs 17.2 pg/mL, P <.001), sFlt-1/PlGF (2 vs 4.7, P <.001), and vWF:antigen (88 vs 77.1 IU/dL, P <.01). There was a strong correlation of ferritin with PlGF (r =.653, P <.001) and with vWF:antigen (r =.503, P =.003). Conclusions: In this study, we demonstrated an association between increased PlGF and iron overload and the degree of tissue hypoxia in patients with NTDT. High vWF:antigen expressing endothelial damage may be associated with specific NTDT comorbidities. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
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