TY - JOUR
TI - Low and high body mass index in hidradenitis suppurativa patients—different subtypes?
AU - Theut Riis, P.
AU - Saunte, D.M.
AU - Benhadou, F.
AU - del Marmol, V.
AU - Guillem, P.
AU - El-Domyati, M.
AU - Abdel-Wahab, H.
AU - Antoniou, C.
AU - Dessinioti, C.
AU - Gürer, M.A.
AU - Beksaç, B.
AU - Szepietowski, J.C.
AU - Matusiak, L.
AU - Emtestam, L.
AU - Lapins, J.
AU - Riad, H.
AU - Doss, N.
AU - Massa, A.F.
AU - Hamzavi, I.
AU - Nicholson, C.
AU - Dolenc-Voljc, M.
AU - Kim, K.H.
AU - Ohn, J.
AU - Zouboulis, C.C.
AU - Karagiannidis, I.
AU - Mokos, Z.B.
AU - Durinec, P.
AU - Jemec, G.B.E.
JO - Journal of the European Academy of Dermatology and Venereology
PY - 2018
VL - 32
TODO - 2
SP - 307-312
PB - Wiley-Blackwell Publishing Ltd
SN - 0926-9959, 1468-3083
TODO - 10.1111/jdv.14599
TODO - adult;  Article;  body mass;  controlled study;  cross-sectional study;  descriptive research;  disease severity;  exploratory research;  family history;  female;  human;  major clinical study;  male;  obesity;  prediction;  priority journal;  rash;  smoking;  suppurative hidradenitis;  young adult;  classification;  comparative study;  complication;  genetics;  onset age;  protection;  risk factor;  severity of illness index;  suppurative hidradenitis, Adult;  Age of Onset;  Body Mass Index;  Cross-Sectional Studies;  Female;  Hidradenitis Suppurativa;  Humans;  Male;  Obesity;  Protective Factors;  Risk Factors;  Severity of Illness Index;  Smoking;  Young Adult
TODO - Introduction: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. Materials and method: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. Results: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. Discussion: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change. © 2017 European Academy of Dermatology and Venereology
ER -