TY - JOUR
TI - Multiple sclerosis and Parkinson’s disease: the two faces of neurodegeneration. Report of the first Greek case and review of the literature
AU - Bougea, A.
AU - Kapaki, E.
AU - Paraskevas, G.P.
AU - Kilidireas, K.
AU - Andreadou, E.
JO - Neurological Sciences
PY - 2015
VL - 36
TODO - 12
SP - 2281-2285
PB - Springer-Verlag Italia s.r.l.
SN - 1590-1874, 1590-3478
TODO - 10.1007/s10072-015-2308-9
TODO - alpha synuclein;  dopamine transporter;  immunoglobulin G;  ioflupane i 123;  levodopa;  oligoclonal band;  alpha synuclein, adult;  Article;  brain atrophy;  brain damage;  case report;  cerebrospinal fluid;  clonus;  demyelination;  drug dose titration;  enzyme linked immunosorbent assay;  Expanded Disability Status Scale;  female;  Greece;  human;  middle aged;  Mini Mental State Examination;  motor dysfunction;  multiple sclerosis;  neuroimaging;  nuclear magnetic resonance imaging;  Parkinson disease;  parkinsonism;  putamen;  rigidity;  spasticity;  thalamus;  Unified Parkinson Disease Rating Scale;  weakness;  white matter lesion;  brain;  complication;  differential diagnosis;  multiple sclerosis;  Parkinson disease;  Parkinsonian Disorders;  pathology;  treatment outcome, alpha-Synuclein;  Brain;  Diagnosis, Differential;  Female;  Humans;  Middle Aged;  Multiple Sclerosis;  Parkinson Disease;  Parkinsonian Disorders;  Treatment Outcome
TODO - There is still an open debate whether multiple sclerosis (MS) lesions can cause parkinsonian symptoms, or the coexistence of both diseases in the same patient is accidental. Moreover, α-synuclein (α Syn), the hallmark of Parkinson’s disease (PD) seems also to play a crucial role in MS. So far, 42 cases of co-occurrence of parkinsonism and MS have been reported, but CSF α Syn measurement is lacking. To our knowledge, we report the first case with concomitant MS and PD diagnosis based on both clinico-radiological and CSF α Syn findings and review of literature. © 2015, Springer-Verlag Italia.
ER -