TY - JOUR
TI - Similarities in Coronary Function and Myocardial Deformation Between Psoriasis and Coronary Artery Disease: The Role of Oxidative Stress and Inflammation
AU - Ikonomidis, I.
AU - Makavos, G.
AU - Papadavid, E.
AU - Varoudi, M.
AU - Andreadou, I.
AU - Gravanis, K.
AU - Theodoropoulos, K.
AU - Pavlidis, G.
AU - Triantafyllidi, H.
AU - Parissis, J.
AU - Paraskevaidis, I.
AU - Rigopoulos, D.
AU - Lekakis, J.
JO - Canadian Journal of Cardiology
PY - 2015
VL - 31
TODO - 3
SP - 287-295
PB - Pulsus Group Inc.
SN - 0828-282X
TODO - 10.1016/j.cjca.2014.11.002
TODO - beta adrenergic receptor blocking agent;  cyclosporin;  hydroxymethylglutaryl coenzyme A reductase inhibitor;  interleukin 6;  malonaldehyde;  biological marker;  interleukin 6;  malonaldehyde, adult;  angiocardiography;  arterial stiffness;  arterial wall thickness;  Article;  augmentation index;  blood vessel function;  brachial artery;  cardiovascular risk;  controlled study;  coronary artery disease;  coronary artery function;  diastolic blood pressure;  Doppler echocardiography;  drug use;  echocardiography;  female;  heart disease;  heart left ventricle failure;  human;  hyperlipidemia;  hypertension;  major clinical study;  male;  myocardial deformation;  oxidative stress;  psoriasis;  Psoriasis Area and Severity Index;  Psoriasis Severity Index;  pulse wave;  smoking;  systolic blood pressure;  two dimensional echocardiography;  angiography;  arterial wall thickness;  blood;  case control study;  coronary artery blood flow;  coronary artery disease;  heart left ventricle function;  inflammation;  middle aged;  pathophysiology;  predictive value;  psoriasis;  reproducibility;  sensitivity and specificity;  severity of illness index;  vasodilatation, Adult;  Angiography;  Biological Markers;  Brachial Artery;  Carotid Intima-Media Thickness;  Case-Control Studies;  Coronary Artery Disease;  Coronary Circulation;  Echocardiography, Doppler;  Female;  Humans;  Inflammation;  Interleukin-6;  Male;  Malondialdehyde;  Middle Aged;  Oxidative Stress;  Predictive Value of Tests;  Psoriasis;  Pulse Wave Analysis;  Reproducibility of Results;  Sensitivity and Specificity;  Severity of Illness Index;  Vasodilation;  Ventricular Dysfunction, Left
TODO - Background: Psoriasis has been associated with increased risk for coronary artery disease (CAD). We investigated the presence of vascular and subclinical left ventricular (LV) dysfunction in patients with psoriasis compared with patients with CAD. Methods: We compared 59 patients with psoriasis without evidence of CAD (psoriasis area and severity index [PASI], 11.5 ± 8) with 59 patients with angiographically documented CAD and 40 controls. We measured (1) the carotid-femoral pulse wave velocity (PWVc) and central augmentation index (CAI), (2) coronary flow reserve (CFR) by Doppler echocardiography, (3) flow-mediated dilation (FMD) of the brachial artery and carotid intima media thickness (IMT), (4) LV global longitudinal strain (GLS) and GLS rate (GLSR) using speckle tracking echocardiography, and (5) malondialdehyde (MDA) and interleukin-6 (IL-6) levels. Results: Patients with psoriasis had higher PWVc, CAI, IMT, MDA, and IL-6 levels and lower FMD, CFR, GLS, and GLSR than did controls (. P<0.05), but they had values of these markers that were similar to those of patients with CAD (. P > 0.05) after adjustment for atherosclerotic risk factors: (PWVc [m/s], 10.4 ± 1.8 vs 8.6 ± 1.5 vs 10.3 ± 2, respectively; CFR, 2.4 ± 0.1 vs 3.4 ± 0.6 vs 2.6 ± 0.6, respectively; GLS [%],-16.2 ± 4 vs-21.9 ± 1.6 vs-16.6 ± 4.5, respectively; GLSR [L/sec],-0.85 ± 0.2 vs-1.2 ± 0.12 vs-0.9 ± 0.4, respectively; MDA [nM/L], 1.68 vs 1.76 vs 1.01, respectively; IL-6 [pg/mL], 2.26 vs 2.2 vs 1.7, respectively; P < 0.05 for all comparisons). PASI was related to IMT (. r= 0.67; P < 0.01). Decreased GLS was associated with increased MDA, IL-6, PWVc, CAI, and reduced CFR (. P < 0.05). Conclusions: Psoriasis and CAD present similar vascular and LV myocardial dysfunction, possibly because of similar underlying inflammatory and oxidative stress processes. Vascular dysfunction in psoriasis is linked to abnormal LV myocardial deformation. © 2015 Canadian Cardiovascular Society.
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