TY - JOUR
TI - Acute Haemodynamic and Echocardiographic Effects of Multiple Configurations of Left Ventricular Pacing Sites in Acute Myocardial Infarction: Experimental Study
AU - Matthaios, I.
AU - Kaladaridou, A.
AU - Skaltsiotes, E.
AU - Agrios, J.
AU - Antoniou, A.
AU - Georgiopoulos, G.
AU - Papadopoulou, E.
AU - Pamboucas, C.
AU - Toumanidis, S.
JO - Heart, Lung and Circulation
PY - 2017
VL - 26
TODO - 4
SP - 383-394
PB - Elsevier Ireland Ltd
SN - 1443-9506, 1444-2892
TODO - 10.1016/j.hlc.2016.07.016
TODO - acute heart infarction;  animal experiment;  Article;  controlled study;  heart hemodynamics;  heart left ventricle apex lateral wall;  heart left ventricle basal anterior wall;  heart left ventricle basal posterior wall;  heart left ventricle function;  heart right ventricle apex;  heart right ventricle function;  heart ventricle pacing;  nonhuman;  pacemaker;  real time ultrasound scanner;  sinus rhythm;  speckle tracking echocardiography;  animal;  biological model;  heart pacing;  heart ventricle;  hemodynamics;  Myocardial Infarction;  pathophysiology;  pig;  software, Animals;  Cardiac Pacing, Artificial;  Heart Ventricles;  Hemodynamics;  Models, Cardiovascular;  Myocardial Infarction;  Software;  Swine
TODO - Background Left ventricular (LV) pacing is unsuccessful in a significant number of patients, mainly due to sub-optimal LV pacing location. Nevertheless, data about the impact of different pacing sites on LV function in ischaemic myocardium are scarce. The purpose of this study was to investigate the effect of combinations of alternative LV pacing sites on LV mechanics after experimental acute anterior myocardial infarction (AMI), in order to define the optimal configuration. Methods Atrioventricular epicardial pacing at alternative pacing sites was performed in 16 healthy pigs simultaneously, after experimental AMI. Standard right ventricular (RV) apical pacing was combined with: i) LV apex lateral wall; ii) LV basal posterior wall; iii) LV basal anterior wall, and; iv) LV basal anterior wall + LV basal posterior wall. Moreover the pacing configurations of, v) LV basal posterior wall + LV apex lateral wall; vi) LV basal posterior wall + LV basal anterior wall, and; vii) LV basal anterior wall + LV apex lateral wall were also investigated. Haemodynamic parameters, together with classic and novel echocardiographic indices were used, to evaluate the effect of each pacing combination. A speckle tracking technique using EchoPAC software was used. Results After AMI, the pacing combination of LV apex lateral wall and LV basal posterior wall had the most favourable effect on LV function, leading to similar haemodynamic and torsional effects with sinus rhythm (all variables p>0.05). Conclusions In pig hearts after AMI, the combination of pacing LV apex lateral wall and LV basal posterior wall managed to maintain the LV function at a level comparable to the sinus rhythm. © 2016 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)
ER -