TY - JOUR
TI - Chemokine CXCL-1 expression in the subretinal fluid during rhegmatogenous retinal detachment
AU - Symeonidis, C.
AU - Androudi, S.
AU - Rotsos, T.
AU - Moschos, M.M.
AU - Souliou, E.
AU - Dimitrakos, S.A.
AU - Diza, E.
JO - Ocular Immunology and Inflammation
PY - 2014
VL - 22
TODO - 6
SP - 449-453
PB - LIBRAPHARM/INFORMA HEALTHCARE
SN - 0927-3948, 1744-5078
TODO - 10.3109/09273948.2013.863942
TODO - CXCL1 chemokine;  biological marker;  CXCL1 chemokine, adult;  age;  aged;  Article;  clinical article;  clinical feature;  controlled study;  correlational study;  disease course;  disease duration;  disease severity;  female;  human;  male;  middle aged;  protein expression;  protein function;  retina detachment;  subretinal fluid;  vitreoretinopathy;  biosynthesis;  complication;  enzyme linked immunosorbent assay;  follow up;  metabolism;  Retinal Detachment;  subretinal fluid;  very elderly;  Vitreoretinopathy, Proliferative;  young adult, Adult;  Aged;  Aged, 80 and over;  Biological Markers;  Chemokine CXCL1;  Enzyme-Linked Immunosorbent Assay;  Female;  Follow-Up Studies;  Humans;  Male;  Middle Aged;  Retinal Detachment;  Subretinal Fluid;  Vitreoretinopathy, Proliferative;  Young Adult
TODO - Purpose: To investigate the expression of chemokine CXCL-1 in the subretinal fluid (SRF) during rhegmatogenous retinal detachment (RRD) and identify potential correlations with number of quadrants involved and duration of the detachment. Methods and Results: Inclusion criteria were patients aged 18 years or older and primary RRD possibly complicated by proliferative vitreoretinopathy (PVR). CXCL-1 levels were measured in 36 SRF samples from 36 RRD patients. Mean CXCL-1 levels (102±37pg/mL) were significantly higher (p=0.050) compared to controls. CXCL-1 levels correlated significantly with age (p=0.001) and RRD duration (p=0.002). Maximum CXCL-1 levels coincided with total RRD, 29- to 60-day duration and PVR grade C. Conclusions: The findings of this study may contribute to increased understanding regarding the role of CXCL-1 during the onset and progression of the wound healing process in the context of RRD and PVR. © 2014 Informa Healthcare USA, Inc.
ER -