TY - JOUR
TI - Agenesis of ductus venosus in sequential first and second trimester screening
AU - Iliescu, D.G.
AU - Cara, M.L.
AU - Tudorache, S.
AU - Antsaklis, P.
AU - Novac, L.V.
AU - Antsaklis, A.
AU - Cernea, N.
JO - Prenatal Diagnosis
PY - 2014
VL - 34
TODO - 11
SP - 1099-1105
PB - John Wiley and Sons Ltd
SN - 0197-3851, 1097-0223
TODO - 10.1002/pd.4434
TODO - agenesis;  Article;  chromosome aberration;  congenital heart malformation;  diagnostic accuracy;  disease association;  ductus venosus;  ductus venosus agenesis;  fetus;  fetus disease;  first trimester pregnancy;  human;  major clinical study;  pregnancy outcome;  prenatal screening;  prevalence;  priority journal;  prospective study;  second trimester pregnancy;  vein malformation;  adult;  Cardiovascular Abnormalities;  Chromosome Disorders;  congenital malformation;  echography;  female;  fetus echography;  fetus heart;  follow up;  pregnancy;  statistics and numerical data;  umbilical vein, Adult;  Cardiovascular Abnormalities;  Chromosome Aberrations;  Chromosome Disorders;  Female;  Fetal Heart;  Follow-Up Studies;  Humans;  Pregnancy;  Pregnancy Outcome;  Pregnancy Trimester, First;  Pregnancy Trimester, Second;  Prevalence;  Ultrasonography, Prenatal;  Umbilical Veins
TODO - Objective: The goal of this study is to evaluate the potential of first trimester (FT) screening in the diagnosis of agenesis of the ductus venosus (ADV) and to study its prevalence in a low-risk population, the associated conditions, and pregnancy outcome. Method: Prospective, sequential screening study at two tertiary units with morpho-functional evaluation of the ductus venosus during the first and second trimester screening. We quantified the FT detection rate, prevalence, and associated conditions: umbilical shunting type, concomitant anomalies, and outcome. Results: In 6114 consecutive pregnancies, we identified 11 cases of ADV. Ten (91%) were identified during the FT examination. The prevalence was 1 in 556, similar for both centers (1/478 vs. 1/691). Major structural defects and fetal effusions were detected in 8 (73%). twenty two percent had a major chromosomal abnormality. In 3 cases, the anomaly was isolated and had normal outcome, independent of liver by-pass, caliber of the shunt, and NT thickness. Conclusions: Agenesis of the ductus venosus can be detected during FT. The early detection of ADV is important given its high association with major abnormalities. © 2014 John Wiley & Sons, Ltd.
ER -