TY - JOUR
TI - Embryonal tumor with abundant neuropil and true rosettes: A systematic literature review and report of 2 new cases
AU - Alexiou, G.A.
AU - Stefanaki, K.
AU - Vartholomatos, G.
AU - Sfakianos, G.
AU - Prodromou, N.
AU - Moschovi, M.
JO - Journal of Child Neurology
PY - 2013
VL - 28
TODO - 12
SP - 1709-1715
PB - SAGE Publications Inc.
SN - 0883-0738, 1708-8828
TODO - 10.1177/0883073812471434
TODO - chaperonin 60;  choline;  cisplatin;  creatine;  cyclophosphamide;  cytokeratin 18;  cytokeratin 8;  cytokeratin AE1;  cytokeratin AE3;  epithelial membrane antigen;  etoposide;  glial fibrillary acidic protein;  heat shock protein 27;  heat shock protein 40;  heat shock protein 70;  heat shock protein 90;  heat shock protein 90alpha;  inositol;  methotrexate;  n acetylaspartic acid;  neurofilament protein;  protein bcl 2;  protein p53;  synaptophysin;  tubulin;  unclassified drug;  vincristine, adjuvant chemotherapy;  anterior fontanel;  article;  brain atrophy;  brain fourth ventricle;  brain ventricle peritoneum shunt;  cancer surgery;  case report;  computer assisted tomography;  DNA determination;  embryo cell;  embryonal tumor with abundant neuropil and true rosette;  follow up;  hematopoietic stem cell;  histology;  human;  hydrocephalus;  immunohistochemistry;  immunoreactivity;  infant;  intracranial pressure;  male;  missense mutation;  mitosis rate;  nerve cell differentiation;  neuroectoderm tumor;  nuclear magnetic resonance spectroscopy;  ornithine transcarbamylase deficiency;  patient referral;  physical examination;  posterior fossa;  priority journal;  protein expression;  rhabdoid tumor;  seizure;  teratoma;  tumor suppressor gene;  vomiting;  weight reduction;  Brain Neoplasms;  Neoplasms, Germ Cell and Embryonal;  neuropil;  pathology, Brain Neoplasms;  Humans;  Infant;  Male;  Neoplasms, Germ Cell and Embryonal;  Neuropil
TODO - Embryonal tumor with abundant neuropil and true rosettes has been recently defined as a distinct central nervous system embryonal neoplasm, although it was initially regarded as a subtype of central nervous system primitive neuroectodermal tumor. To date 70 cases have been reported. We have performed a literature review and we present 2 new cases. Analysis of the reported data revealed that radiotherapy, tumor excision and high-dose adjuvant chemotherapy with sequential autologous hematopoietic stem cell rescue have a prognostic significance.
ER -