TY - JOUR
TI - Metabolomics in neonatal life
AU - Fanos, V.
AU - Iacovidou, N.
AU - Puddu, M.
AU - Ottonello, G.
AU - Noto, A.
AU - Atzori, L.
JO - Early Human Development
PY - 2013
VL - 89
TODO - SUPPL.1
SP - S7
PB - Elsevier Ireland Ltd
SN - 0378-3782
TODO - 10.1016/S0378-3782(13)70003-3
TODO - creatine;  creatinine;  dimethylglycine;  inositol;  sarcosine, acute kidney failure;  asphyxia;  asthma;  brain injury;  breast milk;  bronchiolitis;  epigenetics;  gestational age;  heart arrhythmia;  heart ventricle hypertrophy;  human;  hypothermia;  intrauterine growth restriction;  intrauterine infection;  low birth weight;  metabolome;  metabolomics;  neonatology;  nuclear magnetic resonance spectroscopy;  perinatal development;  phenotype;  postnatal development;  prenatal growth;  proton nuclear magnetic resonance;  review;  twins;  umbilical cord blood
TODO - Metabolomics (or metabonomics) is based on the systematic study of the complete set of metabolites in a biological sample and is considered the most innovative of the 'omics' sciences. The metabolome is currently regarded as the 'new clinical biochemistry' it is the most predictive phenotype, through consideration of epigenetic differences. Among more than 5000 papers listed in PubMed on this topic in the last three years, less than 60 refer to neonatal life. Aim of this review is to present the clinical applications of metabolomics in neonatology, including results of recent studies performed in experimental models and newborns. © 2013 Elsevier Ireland Ltd.
ER -