TY - JOUR
TI - A diet rich in monounsaturated fatty acids improves the lipid profile of mice previously on a diet rich in saturated fatty acids
AU - Arapostathi, C.
AU - Tzanetakou, I.P.
AU - Kokkinos, A.D.
AU - Tentolouris, N.K.
AU - Vlachos, I.S.
AU - Donta, I.A.
AU - Perrea, K.N.
AU - Perrea, D.N.
AU - Katsilambros, N.L.
JO - International Angiology
PY - 2011
VL - 62
TODO - 8
SP - 636-640
PB - 
SN - 0392-9590
TODO - 10.1177/0003319711403734
TODO - cholesterol;  high density lipoprotein cholesterol;  lipid;  low density lipoprotein cholesterol;  monounsaturated fatty acid;  saturated fatty acid;  triacylglycerol, animal model;  article;  cholesterol blood level;  diet therapy;  hypercholesterolemia;  lipid diet;  lipoprotein blood level;  male;  mouse;  nonhuman;  response time;  treatment duration;  triacylglycerol blood level;  weight gain, Animals;  Dietary Fats;  Disease Models, Animal;  Fatty Acids;  Fatty Acids, Monounsaturated;  Hypercholesterolemia;  Lipids;  Male;  Mice;  Mice, Inbred C57BL;  Treatment Outcome
TODO - This study investigated whether switching from a diet rich in saturated fatty acids (SAFAs) to a diet rich in monounsaturated fatty acids (MUFAs) or to one with equal amounts of MUFAs-SAFAs favorably affects the lipid profile of hypercholesterolemic mice. C57BL/6 mice (n = 82) were allocated into 4 groups. The first group (control, n = 10) was fed standard chow. The 3 remaining groups (n = 24 mice/group) were fed a SAFA-rich diet for 8 weeks and were then allocated for 16 weeks to either a MUFA-rich diet, an equal in MUFAs-SAFAs-rich diet, or continued the previous SAFA-rich diet. After 8 weeks, mice consuming SAFA-rich diet had increased weight, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) levels (P <.05 vs baseline). At week 24, MUFA-rich and MUFA-SAFA rich diets decreased TC and low-density lipoprotein cholesterol (LDL-C) levels (P <.05) compared with week 8. In conclusion, switching to MUFA-rich diets or substituting half of the SAFAs with MUFAs can reverse diet-induced-hypercholesterolemia. © SAGE Publications 2011.
ER -