TY - JOUR TI - Sex-specific trends in prevalence of childhood asthma over 30 years in Patras, Greece AU - Anthracopoulos, M.B. AU - Pandiora, A. AU - Fouzas, S. AU - Panagiotopoulou, E. AU - Liolios, E. AU - Priftis, K.N. JO - Acta Paediatrica, International Journal of Paediatrics PY - 2011 VL - 100 TODO - 7 SP - 1000-1005 PB - SN - null TODO - 10.1111/j.1651-2227.2011.02255.x TODO - article; asthma; child; female; Greece; health survey; human; major clinical study; male; prevalence; priority journal; questionnaire; school child; sex ratio; trend study; urban area; wheezing, Asthma; Child; Cross-Sectional Studies; Female; Greece; Humans; Male; Prevalence; Questionnaires; Respiratory Sounds; Sex Distribution; Urban Health TODO - Aim: According to four surveys conducted during 1978-2003, the prevalence of childhood asthma and wheezing has risen in the city of Patras, Greece, albeit at a decelerating rate. We examined sex-specific wheeze and asthma prevalence in the same urban environment in 2008. Methods: A cross-sectional parental questionnaire survey was performed in 2008 among third and fourth grade schoolchildren (8-9 year old), which was identical to previously conducted surveys in 1978 (n = 3003), 1991 (n = 2417), 1998 (n = 3076) and 2003 (n = 2725). Results: The prevalence of current wheeze and asthma in 1978, 1991, 1998, 2003 and 2008 (n = 2688) was 1.5%, 4.6%, 6.0%, 6.9% and 6.9%, respectively (p for trend <0.001). Respective values for lifetime (ever had) wheeze and asthma in the 1991-2008 surveys were 8.0%, 9.6%, 12.4% and 12.6% (p for trend <0.001). The male:female ratio of current and lifetime wheeze and asthma increased during the 30-year surveillance period (p for trend <0.001). Irrespective of sex, diagnosed asthma declined among current wheezers by 17% (p < 0.001), but not among non-current ones (6.7%, p = 0.16) during 2003-2008. Conclusions: Childhood wheeze and asthma have reached a plateau in an urban environment in Greece, while the male:female ratio increased. Asthma diagnosis declined among schoolage but not preschool wheezers during 2003-2008. © 2011 The Author(s). ER -