TY - JOUR
TI - The photoreceptor layer as a prognostic factor for visual acuity in the secondary epiretinal membrane after retinal detachment surgery: Imaging analysis by spectral-domain optical coherence tomography
AU - Theodossiadis, P.G.
AU - Theodossiadis, G.P.
AU - Charonis, A.
AU - Emfietzoglou, I.
AU - Grigoropoulos, V.G.
AU - Liarakos, V.S.
JO - AJO.  AMERICAN JOURNAL OF OPHTHALMOLOGY
PY - 2011
VL - 151
TODO - 6
SP - 973-980
PB - 
SN - 0002-9394
TODO - 10.1016/j.ajo.2010.12.014
TODO - adult;  article;  clinical article;  controlled study;  epiretinal membrane;  female;  human;  image analysis;  incidence;  male;  optical coherence tomography;  photoreceptor;  priority journal;  prognosis;  retina detachment surgery;  retina fovea;  retina macula lutea;  retrospective study;  treatment outcome;  visual acuity, Epiretinal Membrane;  Female;  Follow-Up Studies;  Humans;  Male;  Middle Aged;  Photoreceptor Cells, Vertebrate;  Postoperative Complications;  Prognosis;  Retinal Detachment;  Retrospective Studies;  Tomography, Optical Coherence;  Visual Acuity
TODO - • Purpose: To study the prognostic factors that influence best-corrected visual acuity (BCVA) outcome in patients with secondary epiretinal membrane (ERM) after retinal detachment surgery. • Design: Retrospective case series. • Methods: Forty-two patients with ERM were divided into macula-on and macula-off groups based on the macular status before retinal detachment surgery and were studied using the same spectral-domain optical coherence tomography device. Several variables, including the integrity of the external limiting membrane (ELM), the status of the photoreceptor inner segment/outer segment (IS/OS) junction line, and central foveal thickness were evaluated in 17 treated and 25 untreated patients. Linear regression analysis was used to determine the best combination of all variables affecting BCVA. • Results: Final BCVA was significantly better in macula-on and macula-off eyes with intact ELMs and IS/OS junction lines (0.35 ± 0.18 logarithm of the minimal angle of resolution [logMAR] and 0.51 ± 0.17 logMAR, respectively) than in macula-off eyes with disrupted or absent ELMs and IS/OS junction lines (0.83 ± 0.17 logMAR and 1.04 ± 0.05 logMAR, respectively; P < .001, analysis of variance). Final BCVA also was better in the treated group than in the controls (0.55 ± 0.31 logMAR and 0.73 ± 0.26 logMAR, respectively; P = .05, t test). ELM and IS/OS junction line integrity were the main variables significantly affecting the final BCVA outcome (β = 0.42; P = .006, linear regression analysis). Disruption of the ELM and IS/OS junction line was observed in 21 of the 42 cases studied. • Conclusions: ERM secondary to retinal detachment surgery is accompanied by a high incidence (50%) of IS/OS junction line and ELM disruption. Among the variables studied, the condition of the IS/OS junction layer and the ELM are the main factors that predict final BCVA after ERM peeling. © 2011 Elsevier Inc. All rights reserved.
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