TY - JOUR
TI - Prognostic significance of angiogenesis in relation to Ki-67, p-53, p-27, and bcl-2 expression in embryonal tumors
AU - Moschovi, M.
AU - Koultouki, E.
AU - Stefanaki, K.
AU - Sfakianos, G.
AU - Tourkantoni, N.
AU - Prodromou, N.
AU - Alexiou, G.A.
JO - Pediatric Neurosurgery
PY - 2011
VL - 47
TODO - 4
SP - 241-247
PB - S Karger AG
SN - 1016-2291, 1423-0305
TODO - 10.1159/000335398
TODO - carboplatin;  cisplatin;  cyclophosphamide;  etoposide;  Ki 67 antigen;  methotrexate;  protein bcl 2;  protein p27;  protein p53;  vincristine, adolescent;  angiogenesis;  article;  benign tumor;  blood vessel;  cancer chemotherapy;  child;  clinical article;  density;  embryonal tumor;  female;  human;  male;  medulloblastoma;  overall survival;  preschool child;  priority journal;  prognosis;  progression free survival;  protein expression;  retrospective study;  rhabdoid tumor;  school child;  teratoma
TODO - Aim: We investigated the angiogenesis and density of newly formed blood vessels in embryonal tumors in relation to Ki-67, bcl-2, p-53 and p-27 expression. Methods: Forty-five children with embryonal tumors were enrolled in the study. Forty patients had a medulloblastoma (MB) and 5 patients had atypical teratoid/rhabdoid tumor (AT/RT). Results: In MB, the 5-year PFS and OS was 62.5 and 70%, respectively. Patients with Ki-67 index >50%, bcl-2 index >30% and higher density of new vessels were associated with worse survival. In the multivariate analysis, Ki-67 index was identified as a factor with independent prognostic power. In AT/RTs, high density of new vessels (>25 HRF) was observed in 3 patients and Ki-67 index over 25% was found in 4 patients. Conclusion: Increased Ki-67, bcl-2 and density of new vessels are of prognostic value for the disease outcome in MB. Copyright © 2012 S. Karger AG, Basel.
ER -