TY - JOUR
TI - Impact of prehypertension on carotid artery intima-media thickening: Actual or masked?
AU - Manios, E.
AU - Michas, F.
AU - Tsivgoulis, G.
AU - Stamatelopoulos, K.
AU - Tsagalis, G.
AU - Koroboki, E.
AU - Alexaki, E.
AU - Papamichael, C.
AU - Vemmos, K.
AU - Zakopoulos, N.
JO - Atherosclerosis
PY - 2011
VL - 214
TODO - 1
SP - 215-219
PB - 
SN - 0021-9150
TODO - 10.1016/j.atherosclerosis.2010.10.032
TODO - adult;  artery intima proliferation;  article;  blood pressure monitoring;  carotid artery;  circadian rhythm;  controlled study;  diastolic blood pressure;  Doppler echography;  female;  human;  hypertension;  major clinical study;  male;  prehypertension;  priority journal;  systolic blood pressure, Blood Pressure;  Blood Pressure Monitoring, Ambulatory;  Carotid Arteries;  Diastole;  Female;  Humans;  Hypertension;  Male;  Middle Aged;  Models, Statistical;  Prevalence;  Systole;  Tunica Intima;  Tunica Media;  Ultrasonography
TODO - Background: Recent studies have reported that prehypertension is associated with increased values of common carotid artery intima-media thickness (CCA-IMT). The aim of this study was to assess the impact of daytime ambulatory blood pressure (BP) levels on the association of prehypertension with CCA intima-media thickening in prehypertensive subjects. Methods: A total of 807 subjects with office systolic BP < 140 and diastolic BP < 90 mmHg, underwent 24 h ambulatory BP (ABP) monitoring and carotid artery ultrasonographic measurements. The study population was divided into 3 groups according to office and daytime ABP levels: (1) normotensives: subjects with office BP < 120/80 mmHg and daytime ambulatory BP values within the normal range, (2) actual prehypertensives: individuals with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and daytime ambulatory BP values within the normal range and (3) prehypertensives with masked hypertension (MH): patients with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and elevated daytime ambulatory BP values. Results: Prehypertensive patients with MH had higher (p< 0.01) CCA-IMT values (0.712 mm; 95%CI: 0.698-0.725) than actual prehypertensives (0.649 mm; 95%CI: 0.641-0.656) and normotensives (0.655 mm; 95%CI: 0.641-0.670) even after adjustment for baseline characteristics. Normotensives and actual prehypertensives did not differ significantly regarding CCA-IMT values (p> 0.05). After adjusting for potential confounders, (including demographic characteristics, vascular risk factors, and office BP) prehypertension with MH was independently (p< 0.01) associated with a 0.06 mm increment in CCA-IMT (95%CI: 0.03-0.09). Conclusions: Patients with office BP levels in the prehypertensive range, who also have elevated daytime ABP levels, had higher CCA-IMT values than patients with prehypertension with normal daytime ABP values and normotensive individuals. © 2010 Elsevier Ireland Ltd.
ER -