TY - JOUR
TI - Whole blood interferon-γ release assay is a useful tool for the diagnosis of tuberculosis infection particularly among bacille calmette guèrin-vaccinated children
AU - Tsolia, M.N.
AU - Mavrikou, M.
AU - Critselis, E.
AU - Papadopoulos, N.G.
AU - Makrinioti, H.
AU - Spyridis, N.P.
AU - Metsou, F.
AU - Tsagaraki, M.
AU - Koulouri, M.
AU - Kafetzis, D.A.
JO - The Pediatric Infectious Disease Journal
PY - 2010
VL - 29
TODO - 12
SP - 1137-1140
PB - 
SN - 0891-3668, 1532-0987
TODO - 10.1097/INF.0b013e3181ebfe8a
TODO - BCG vaccine;  gamma interferon, article;  BCG vaccination;  child;  controlled study;  cytokine release;  diagnostic test accuracy study;  human;  intermethod comparison;  latent tuberculosis;  major clinical study;  pediatrics;  priority journal;  protein determination;  sensitivity and specificity;  skin test;  tuberculin test;  tuberculosis, Adolescent;  BCG Vaccine;  Blood;  Cells, Cultured;  Child;  Child, Preschool;  Diagnosis, Differential;  Humans;  Infant;  Infant, Newborn;  Interferon-gamma;  Sensitivity and Specificity;  Tuberculin Test;  Tuberculosis
TODO - The performance of QuantiFERON-tuberculosis (TB) Gold-In-Tube assay was compared with the tuberculin skin test for the diagnosis of TB among children. It was shown that among non-Bacille Calmette Guèrin immunized children, agreement between tests was excellent both in those with TB disease and in TB contacts. Among Bacille Calmette Guèrin-immunized children, agreement was fair in those with active disease and poor among TB contacts. It is concluded that QuantiFERON-TB Gold-In-Tube compares with the tuberculin skin test in the diagnosis of TB disease and latent tuberculosis infection in TB contacts among children and has enhanced specificity. © 2010 Lippincott Williams & Wilkins.
ER -