TY - JOUR
TI - Immunohistochemical expression of matrix metalloproteinases, their tissue inhibitors, and cathepsin-D in ovarian endometriosis: Correlation with severity of disease
AU - Protopapas, A.
AU - Markaki, S.
AU - Mitsis, T.
AU - Milingos, D.
AU - Athanasiou, S.
AU - Haidopoulos, D.
AU - Loutradis, D.
AU - Antsaklis, A.
JO - International Journal of Fertility and Sterility
PY - 2010
VL - 94
TODO - 6
SP - 2470-2472
PB - 
SN - null
TODO - 10.1016/j.fertnstert.2010.03.007
TODO - cathepsin D;  gelatinase A;  gelatinase B;  interstitial collagenase;  matrix metalloproteinase;  stromelysin;  tissue inhibitor of metalloproteinase;  tissue inhibitor of metalloproteinase 1;  tissue inhibitor of metalloproteinase 2, adult;  article;  clinical article;  disease severity;  endometriosis;  enzyme synthesis;  female;  human;  immunohistochemistry;  pelvis pain syndrome;  priority journal;  protein expression;  uterus surgery, Adolescent;  Adult;  Biological Markers;  Case-Control Studies;  Cathepsin D;  Endometriosis;  Female;  Humans;  Immunohistochemistry;  Matrix Metalloproteinases;  Ovarian Diseases;  Severity of Illness Index;  Tissue Inhibitor of Metalloproteinases;  Young Adult
TODO - In this study the immunohistochemical expression of matrix metalloproteinases 1, 2, 3, and 9, tissue inhibitors (TIMPs) 1 and 2, and cathepsin-D in ovarian endometriomas were correlated with the clinical severity of endometriosis (i.e., presence of chronic pelvic pain [CPP] and American Society of Reproductive Medicine [ASRM] scores). Positive expression of proteases and their inhibitors was found more frequently in cases with low ASRM scores, whereas presence of CPP correlated significantly with absence of expression of TIMPs 1 and 2, indicating, first, that production of these enzymes is more active during the initial phases of the evolution of ovarian endometriosis, declining as fibrosis develops, and second, that expression of TIMPs seems to play a role in the development of CPP. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.
ER -