TY - JOUR
TI - High-sensitivity CRP is correlated with neurologic symptoms and plaque instability in patients with severe stenosis of the carotid bifurcation
AU - Papas, T.T.
AU - Maltezos, C.K.
AU - Papanas, N.
AU - Kopadis, G.
AU - Marakis, J.
AU - Maltezos, E.
AU - Bastounis, E.
JO - Italian Journal of Vascular and Endovascular Surgery
PY - 2008
VL - 42
TODO - 3
SP - 249-255
PB - 
SN - 1824-4777
TODO - 10.1177/1538574408314437
TODO - C reactive protein;  endothelial leukocyte adhesion molecule 1, adult;  article;  atherosclerotic plaque;  cardiovascular risk;  carotid artery bifurcation;  carotid artery obstruction;  clinical feature;  digital subtraction angiography;  disease association;  echography;  endarterectomy;  female;  human;  inflammation;  macrophage;  major clinical study;  male;  neurologic disease;  protein blood level, Aged;  Angiography, Digital Subtraction;  Biological Markers;  C-Reactive Protein;  Carotid Stenosis;  E-Selectin;  Endarterectomy, Carotid;  Female;  Humans;  Ischemic Attack, Transient;  Macrophages;  Male;  Middle Aged;  Predictive Value of Tests;  Severity of Illness Index;  Stroke;  Ultrasonography, Doppler, Duplex
TODO - The aim of this study is to investigate the correlation of high-sensitivity C-reactive protein and E-selectin with clinical manifestations and plaque characteristics in 88 patients (69 with and 19 without neurological symptoms) with high-grade stenosis of the carotid bifurcation who underwent endarterectomy. The grade of stenosis was quantified by duplex ultrasonography and digital subtraction angiography. Preoperatively, serum high-sensitivity C-reactive protein and E-selectin were measured. Postoperatively, carotid plaque morphology was established according to the American Heart Association classification. High-sensitivity C-reactive protein levels were significantly (P <.001) higher in symptomatic than in asymptomatic patients, as well as in patients with unstable compared with those with stable plaques (P <.001). Serum high-sensitivity C-reactive protein levels correlated significantly ( P <.05) with macrophage count on the plaque. In conclusion, serum high-sensitivity C-reactive protein levels are associated with presence of neurological symptoms and plaque instability in patients with high-grade stenosis of the carotid bifurcation. © 2008 Sage Publications.
ER -