TY - JOUR
TI - Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility
AU - Matalliotakis, I.M.
AU - Cakmak, H.
AU - Mahutte, N.
AU - Fragouli, Y.
AU - Arici, A.
AU - Sakkas, D.
JO - International Journal of Fertility and Sterility
PY - 2007
VL - 88
TODO - 6
SP - 1568-1572
PB - 
SN - null
TODO - 10.1016/j.fertnstert.2007.01.037
TODO - chorionic gonadotropin;  gonadotropin;  human menopausal gonadotropin;  leuprorelin;  prostaglandin E2;  urofollitropin, adult;  article;  birth rate;  case control study;  controlled study;  disease course;  endometriosis;  female;  fertilization;  fertilization in vitro;  hormonal therapy;  human;  infertility;  laparoscopic surgery;  live birth;  major clinical study;  nidation;  oocyte;  ovary hyperstimulation;  pregnancy;  priority journal;  prostaglandin blood level;  retrospective study;  spontaneous abortion;  uterine tube, Adult;  Case-Control Studies;  Delivery, Obstetric;  Embryo Implantation;  Endometriosis;  Female;  Fertilization in Vitro;  Gonadotropins;  Humans;  Infertility, Female;  Ovulation Induction;  Pregnancy;  Pregnancy Outcome;  Pregnancy Rate;  Retrospective Studies;  Treatment Outcome
TODO - Objective: To investigate the response to controlled ovarian hyperstimulation and ART outcomes in women with advanced-stage endometriosis and previous surgeries at the Yale IVF program between 1996 and 2002. Design: Retrospective case control study. Setting: Academic medical center. Patient(s): The study group consisted of 68 women who previously undergone laparoscopic surgery for advanced-stage endometriosis. The control group included 106 women with tubal-factor infertility. The women with endometriosis underwent 133 IVF-ET cycles and the control group 208 cycles. Intervention(s): Controlled ovarian hyperstimulation and IVF-ET. Main Outcome Measure(s): Response to gonadotropins, fertilization, cleavage, implantation, pregnancy, miscarriage, and live birth rates. Result(s): Lower peak E2 levels, higher total gonadotropin requirements, lower oocyte yield, and higher cancellation rates were found in women with endometriosis compared with tubal-factor control subjects. However, no differences were found in fertilization, cleavage, implantation, pregnancy, miscarriage, and delivery rates between the endometriosis and tubal-factor groups. Conclusion(s): Women with advanced-stage endometriosis who have undergone previous surgery respond less well to gonadotropins than women with tubal-factor infertility. However, implantation, pregnancy, and delivery rates are similar, suggesting that embryo quality and uterine receptivity remains unaffected despite diminished ovarian reserve in women with endometriosis. © 2007 American Society for Reproductive Medicine.
ER -