TY - JOUR
TI - Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network
AU - Tovo, P.-A.
AU - Newell, M.-L.
AU - Coll, O.
AU - de Tejada, B.M.
AU - Lanari, M.
AU - Bosi, I.
AU - Papa, I.
AU - Zanetti, A.
AU - Contreras, J.R.
AU - Manzanares, A.
AU - Ramos, J.T.
AU - Vegnente, A.
AU - Iorio, R.
AU - Fabris, C.
AU - Bandelloni, A.M.
AU - Tibaldi, C.
AU - Ciria, L.M.
AU - Palomba, E.
AU - Riva, C.
AU - Scolfaro, C.
AU - Buffolano, W.
AU - Scotese, I.
AU - Micco, A.
AU - Marcellini, M.
AU - Sartorelli, M.R.
AU - Mattia, S.
AU - Bohlin, A.-B.
AU - Fischler, B.
AU - Lindgren, S.
AU - Lindh, G.
AU - Maccabruni, A.
AU - Pacati, I.
AU - Arlandi, L.
AU - Polywka, S.
AU - Butler, K.
AU - De Maria, A.
AU - Bassetti, D.
AU - Fioredda, F.
AU - Boni, S.
AU - Gotta, C.
AU - Mazza, A.
AU - Grosch-Wörner, I.
AU - Sperling, C.F.
AU - Quinti, I.
AU - Scaravelli, G.
AU - Cigna, P.
AU - Cilla, G.
AU - Echeverria, J.
AU - Souayah, H.
AU - Grossman, D.
AU - Levy, J.
AU - Bona, G.
AU - Mok, J.Y.Q.
AU - Fontelos, P.M.
AU - Arrieta, J.V.
AU - Asensi-Botet, F.
AU - Otero, M.C.
AU - Pérez-Tamarit, D.
AU - Zuin, G.
AU - Saccani, B.
AU - Zuccotti, G.V.
AU - Riva, E.
AU - Gamboni, A.
AU - Wejstal, R.
AU - Norkrans, G.
AU - Scherpbier, H.
AU - Mûr, A.
AU - Viñolas, M.
AU - Extremera, A.R.
AU - Roura, L.C.
AU - McBertran Sanges, J.
AU - McLeon Leal, J.A.
AU - Rodriguez, A.
AU - Sarrión-Auñón, A.
AU - Corrias, A.
AU - Boucher, C.
AU - Hatzakis, A.
AU - Grella, P.
JO - British Journal of Obstetrics and Gynaecology
PY - 2001
VL - 108
TODO - 4
SP - 371-377
PB - 
SN - 0306-5456
TODO - 10.1016/S0306-5456(00)00088-7
TODO - adult;  article;  bottle feeding;  breast feeding;  cesarean section;  child;  comparative study;  delivery;  hepatitis C;  Hepatitis C virus;  human;  Human immunodeficiency virus infection;  infant feeding;  infection risk;  major clinical study;  priority journal;  retrospective study;  superinfection;  vaginal delivery;  virus transmission, Adult;  Bottle Feeding;  Breast Feeding;  Cesarean Section;  Delivery, Obstetric;  Disease Transmission, Vertical;  Female;  Hepatitis C;  Humans;  Infant;  Infant, Newborn;  Pregnancy;  Pregnancy Complications, Infectious;  Prospective Studies;  Retrospective Studies;  Risk Factors
TODO - Objective: To investigate the effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus. Design: Pooled retrospective analysis of prospectively collected data. Sample: Data on hepatitis C virus seropositive mothers and their children identified around delivery were sent from 24 centres of the European Paediatric Hepatitis C Virus Network. Main outcome measures: Hepatitis C virus infection status of children born to hepatitis C virus infected women. Results: A total of 1,474 hepatitis C virus infected women were identified, of whom 503 (35%) were co-infected with HIV. Co-infected women were more than twice as likely to transmit hepatitis C virus to their children than women with hepatitis C virus infection alone. Overall 9.2% (136/1474) of children were hepatitis C virus infected. Among the women with hepatitis C virus infection-only, multivariate analyses did not show a significant effect of mode of delivery and breastfeeding: caesarean section vs vaginal delivery OR = 1.17, P: 0.66; breastfed versus non-breastfed OR = 1.07, P = 0.83. However, HIV co-infected women delivered by caesarean section were 60% less likely to have an infected child than those delivered vaginally (OR = 0.36, P = 0.01) and those who breastfed were about four times more likely to infect their children than those who did not (OR = 6.41, P: 0.03). HIV infected children were three to four times more likely also to be hepatitis C virus infected than children without HIV infection (crude OR = 3.76, 95% CI 1.89-7.41). Conclusions: These results do not support a recommendation of elective caesarean section or avoidance of breastfeeding for women with hepatitis C virus infection only, but the case for HIV infected women undergoing caesarean section delivery and avoiding breastfeeding is strengthened if they are also hepatitis C virus infected.
ER -