TY - JOUR
TI - Myofibroblastoma of the breast: Cytologic, histologic, immunohistochemical, and ultrastructural findings in two cases with differing cellularity
AU - Deligeorgi-Politi, H.
AU - Kontozoglou, T.
AU - Joseph, M.
AU - Hearn, S.
JO - The Breast Journal
PY - 1997
VL - 3
TODO - 6
SP - 365-371
PB - Blackwell Publishing Inc.
SN - 1075-122X, 1524-4741
TODO - 10.1111/j.1524-4741.1997.tb00195.x
TODO - CD34 antigen;  estrogen receptor;  progesterone receptor, adult;  aged;  article;  aspiration biopsy;  breast biopsy;  breast disease;  breast tumor;  case report;  cell ultrastructure;  differential diagnosis;  electron microscopy;  female;  human;  human cell;  human tissue;  immunohistochemistry;  male;  myofibroblast;  tumor diagnosis
TODO - We present the cytologic, histologic, immunohistochemical, and ultrastructural features of two cases of myofibroblastoma with different cellularity, one paucicellular the other hypercellular. Fine-needle aspiration suggested the diagnosis in the case of the hypercellular tumor of the breast and pointed out the benign nature of the paucicellular case, arising in the breast of a young woman. Immunohistochemistry, showed smooth muscle-specific actin, vimentin, and desmin positivity consistent with myofibroblastic differentiation, in both cases. The positivity of both tumors to CD34 suggests that they may be related to the so-called solitary fibrous tumor. In addition, there was strong progesterone- and weak estrogen-receptor positivity ion the hypercellular case, a novel finding in these tumors, with possible histogenetic implications. Ultrastructural findings in the first case were consistent with the myofibroblastic origin of the tumor.
ER -