TY - JOUR
TI - Use of Naproxen in Ameliorating Induced Paraneoplastic Fever
AU - Tsavaris, N.
AU - Mylonakis, N.
AU - Bacoyiannis, Ch.
AU - Karvounis, N.
AU - Kordossis, T.
AU - Daliani, D.
AU - Karabelis, A.
AU - Kosmidis, P.
JO - Clinical Drug Investigation
PY - 1995
VL - 10
TODO - 1
SP - 8-11
PB - 
SN - 1173-2563
TODO - 10.2165/00044011-199510010-00002
TODO - amoxicillin plus clavulanic acid;  antibiotic agent;  carbenicillin;  cefaclor;  cefamandole;  cefotaxime;  cefoxitin;  ceftriaxone;  cefuroxime;  cotrimoxazole;  gentamicin;  naproxen;  nonsteroid antiinflammatory agent;  tobramycin, article;  breast tumor;  clinical trial;  colorectal tumor;  fever;  head tumor;  human;  human cell;  infection;  kidney tumor;  lung tumor;  major clinical study;  melanoma;  methodology;  oral drug administration;  ovary tumor;  pancreas tumor;  paraneoplastic syndrome;  patient monitoring;  priority journal;  sarcoma;  stomach tumor;  testis tumor;  uterine cervix tumor
TODO - The purpose of this study was to investigate the use of naproxen in patients with paraneoplastic fever. In total, 82 patients were entered in this trial. Tumours diagnosed histologically were: breast 12, testes 2, colorectal 16, lung 15, head and neck 13, renal 6, unknown origin 8, pancreas 3, ovarian 2, cervix uteri 2, gastric 3, melanomas 2 and sarcomas 2. A clinical methodology was followed in order to exclude any possibility of infection. After 5 days of persistent unexplained fever >38°C without any incidence of infection and despite adequate antibiotic treatment, the fever was attributed to the malignancy and patients were treated with oral naproxen 250mg twice a day at 12-hourly intervals. Fever was monitored for 10 days after initiation of treatment with naproxen. Of the 82 patients who received this drug, 18 patients (22%) did not respond to therapy. We then re-evaluated those 18 patients for the possibility of infection: 6 were found to suffer from microbial infections, and 8 received new empiric antibiotic treatment; of these 8, 4 responded. Among the remaining 4 nonresponders, one was found to have a rectal abscess, and the other 3 died shortly afterwards; we were thus unable to follow them up completely. We therefore concluded that the use of nonsteroidal anti-inflammatory drugs, particularly naproxen, in the treatment of paraneoplastic fever is successful in 78% of patients. The persistence of fever in patients who received naproxen might be attributed to an infectious cause. © 1995, Adis International Limited. All rights reserved.
ER -