TY - JOUR
TI - Synergia of a heparinoid and promethazine hydrochloride against liver cell necrosis
AU - Bartsokas, St.K.
AU - Papacharalampous, N.X.
AU - Papadimitriou, D.G.
AU - Katapoti, Z.
JO - Research in Experimental Medicine
PY - 1974
VL - 162
TODO - 3
SP - 235-241
PB - Springer-Verlag
SN - 0300-9130, 1433-8580
TODO - 10.1007/BF01851245
TODO - antihistaminic agent;  eosin;  hematoxylin;  heparinoid;  pentosan polysulfate;  promethazine;  thioacetamide, dose liver function relation;  drug administration;  drug potentiation;  drug toxicity;  intoxication;  liver;  liver injury;  liver necrosis;  rat;  theoretical study;  therapy, Animal;  Drug Synergism;  Drug Therapy, Combination;  Female;  Heparinoids;  Liver Cirrhosis, Experimental;  Male;  Promethazine
TODO - The effects of combined treatment with a heparinoid-sodium pentosan polysulfate - and an antihistamine-promethazine hydrochloride - against thioacetamide-induced rat liver injury were studied. Treatment by promethazine hydrochloride at 0 and 6 hrs by 2.5 and 1.25 mg per 100 g body weight or by 1.5 mg pentosan polysulfate did not afford a real protection against liver injury. The combined, however, of these two incompletely acting schedules treatment inhibited substantially the development of liver cellnecrosis up to 96 hrs. A synergic action of the above protective agents could be supposed. © 1974 Springer-Verlag.
ER -