TY - JOUR
TI - South-to-North gradient in lipid peroxidation in men with stable
coronary artery disease in Europe
AU - Grau, Maria
AU - Guxens, Monica
AU - Subirana, Isaac
AU - Fito, Montserrat
AU - and Covas, Maria-Isabel
AU - Jacquemin, Benedicte
AU - Sunyer, Jordi and
AU - Lanki, Timo
AU - Picciotto, Sally
AU - Bellander, Tom
AU - Katsouyanni,
AU - Klea
AU - Schneider, Alexandra
AU - Peters, Annette
AU - Marrugat, Jaume
AU - and AIRGENE Study Grp
JO - EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
PY - 2007
VL - 28
TODO - 23
SP - 2841-2849
PB - Oxford University Press
SN - null
TODO - 10.1093/eurheartj/ehm446
TODO - atherosclerosis; lipid peroxidation; oxidative stress; epidemiology;
coronary artery disease
TODO - Aims A South-to-North gradient across Europe exists for the incidence of
coronary artery disease (CAD) rates. Low-density lipoprotein (LDL)
oxidation is a hallmark of atherosclerosis and CAD development. The aim
of our study was to determine whether differences exist in the degree of
LDL oxidation in stable CAD patients from different regions of Europe.
Methods and results A cross-sectional multicentre study included 790
stable CAD male subjects aged 35-79 years (61.4 +/- 9.5) from six
European countries in three regions by latitude: Northern (Finland and
Sweden), Central (Germany), and Southern (Greece, Spain, and Italy).
Plasma oxidized LDL (oxLDL) levels were determined. Alcohol intake and
lipid profile were significantly associated with oxLDL. The Italian
participants had the highest oxLDL levels. A sensitivity analysis showed
the models yielded higher adjusted oxLDL values in Northern (63.8 U/L)
than in Central (57.6 U/L) and Southern populations (56.5 U/L), P <
0.001, after excluding Italian subjects. The probability of Southern
Europe scoring the lowest oxLDL levels was > 71% in all fitted models.
Conclusion Our findings suggest a gradient in LDL oxidation from
Southern to Northern Europe that consistently holds for all levels of
LDL, except for Italy; this country displays the highest levels in
Europe, for unknown reasons.
ER -