TY - JOUR
TI - In vitro activity of CAY-1, a saponin from Capsicum frutescens, against
Microsporum and Trichophyton species
AU - Stergiopoulou, Theodouli
AU - De Lucca, Anthony J.
AU - Meletiadis, Joseph
AU - and Sein, Tin
AU - Boue, Stephen M.
AU - Schaufele, Robert
AU - Roilides,
AU - Emmanuel
AU - Ghannoum, Mahmoud
AU - Walsh, Thomas J.
JO - Medical Mycology
PY - 2008
VL - 46
TODO - 8
SP - 805-810
PB - LIBRAPHARM/INFORMA HEALTHCARE
SN - 1369-3786, 1460-2709
TODO - 10.1080/13693780802089831
TODO - dermatophytes; Capsicum frutenses; saponin
TODO - Dermatomycoses are among the world’s most common diseases and their
incidence has increased over recent years, particularly in
immunosuppressed patients. In previous studies, the saponin CAY-1 from
cayenne pepper (Capsicum frutescens), has shown antifungal activities
against Candida albicans and Aspergillus spp. We therefore studied the
in vitro antifungal activity of CAY-1 against non-germinating conidia
and hyphae of clinical isolates of the dermatophytes Trichophyton
mentagrophytes, T. rubrum, T. tonsurans and Microsporum canis. We used a
microdilution method to assess the growth inhibitory activities of CAY-1
against conidia (CLSI document M38-A) and a colorimetric procedure (XTT
method) to investigate the metabolic inhibitory activity of CAY-1
against hyphae. The minimal inhibitory concentrations (complete visual
growth inhibition) of CAY-1 against non-germinating conidia ranged from
10-20 g/ml for all dermatophyte isolates included in this investigation.
In addition, we found 90% inhibition of hyphal metabolic activity of
these same isolates with 10-20 g/ml of CAY-1. Results indicate that
CAY-1 merits further investigation as a potential agent for the
treatment of dermatomycoses.
ER -