TY - JOUR
TI - Folate and vitamin B12 levels in levodopa-treated Parkinson's disease
patients: Their relationship to clinical manifestations, mood and
cognition
AU - Triantafyllou, Nikolaos I.
AU - Nikolaou, Chrysoula
AU - Boufidou, Fotini
AU - and Angelopoulos, Elias
AU - Rentzos, Michael
AU - Kararizou, Evangelia
AU - and Evangelopoulos, Maria-Eleftheria
AU - Vassilpoulos, Dimitrios
JO - Parkinsonism and Related Disorders
PY - 2008
VL - 14
TODO - 4
SP - 321-325
PB - Elsevier Sci Ltd, Exeter, United Kingdom
SN - 1353-8020
TODO - 10.1016/j.parkreldis.2007.10.002
TODO - vitamin B12; brain lateralization; cognition; depression; folate; folic
acid; Parkinson’s disease
TODO - We tested the hypothesis that mood, clinical manifestations and
cognitive impairment of levodopa-treated Parkinson’s disease (PD)
patients are associated with vitamin B12 and folate deficiency. To this
end, we performed this cross-sectional study by measuring serum folate
and vitamin B 12 blood levels in 111 consecutive PD patients.
Levodopa-treated PD patients showed significantly lower serum levels of
folate and vitamin B12 than neurological controls, while depressed
patients had significantly lower serum folate levels as compared to
non-depressed.
Cognitively impaired PD patients exhibited significantly lower serum
vitamin B12 levels as compared to cognitively non-impaired. In
conclusion, lower folate levels were associated with depression, while
lower vitamin B12 levels were associated with cognitive impairment. The
effects of vitamin supplementation merit further attention and
investigation. (c) 2007 Elsevier Ltd. All rights reserved.
ER -