TY - JOUR
TI - Beneficial Effect of Angiotensin II Type 1 Receptor Blocker
Antihypertensive Treatment on Arterial Stiffness: The Role of Smoking
AU - Vyssoulis, Gregory P.
AU - Karpanou, Eva A.
AU - Kyvelou, Stella-Maria G.
AU - and Adamopoulos, Dionysios N.
AU - Antonakoudis, George C. and
AU - Deligeorgis, Alexandros D.
AU - Cokkinos, Dennis V.
AU - Stefanadis,
AU - Christodoulos I.
JO - The Journal of Clinical Hypertension
PY - 2008
VL - 10
TODO - 3
SP - 201-207
PB - Wiley
SN - 1524-6175, 1751-7176
TODO - 10.1111/j.1751-7176.2008.07141.x
TODO - null
TODO - The purpose of the present study was to assess angiotensin receptor
blocker (ARB) treatment on arterial stiffness in select hypertensive
patients and define possible differences between smokers and nonsmokers.
The authors evaluated 81 consecutive, nondiabetic patients (mean age, 52
years; 47 men) with uncomplicated essential hypertension with high
plasma renin activity who were administered monotherapy with irbesartan,
an ARB, at maximal dose. Patients were divided into smokers (n=24) and
nonsmokers (n=57). Carotid-radial pulse wave velocity (PWVc-r),
carotid-femoral pulse wave velocity (PWVc-f) and augmentation index
(AIx) were measured before and 6 months after ARB antihypertensive
treatment. All mean values of elastic effect indices were decreased
after irbesartan monotherapy (AIx, from 26.3% to 21.2% [P<.01];
PWVc-f, from 7.7 m/s to 7.3 m/s [P<.05], and PWVc-r, from 8.9 m/s to
8.3 m/s [P<.001]). When comparing smokers vs nonsmokers, no difference
was noted in AIx and PWVc-f change (P=not significant), while PWVc-r
change was greater in smokers compared with nonsmokers (P<.05). Chronic
ARB treatment may favorably affect arterial stiffness and wave
reflections in hypertensive chronic smokers with elevated plasma renin
levels. J Clin Hypertens (Greenwich). 2008;10:201-207. (C)2008 Le Jacq
ER -