TY - JOUR
TI - Diurnal correlation of ambulatory blood pressure and interstitial
glucose in patients with normal glucose tolerance
AU - Zakopoulos, Nikolaos A.
AU - Dolianitis, Konstantinos J.
AU - Theodorakis,
AU - Michael J.
AU - Manios, Efstathios D.
AU - Alevizaki, Maria and
AU - Stamatelopoulos, Kimon S.
AU - Koroboki, Eleni A.
AU - Spiliopoulou,
AU - Loanna
AU - Anastasiou, Eleni
AU - Mavrikakis, Myron
AU - Moulopoulos,
AU - Spyridon D.
JO - Blood Pressure Monitoring
PY - 2008
VL - 13
TODO - 6
SP - 309-317
PB - Lippincott, Williams & Wilkins
SN - 1359-5237, 1473-5725
TODO - 10.1097/MBP.0b013e32830d4b4a
TODO - ambulatory blood pressure; circadian variation; interstitial glucose
concentration
TODO - Objective Among the physiological variables whose diurnal profile is
governed by circadian rhythmicity, plasma glucose concentrations, and
arterial blood pressure constitute key elements of the physiological
regulation of energy homeostasis. Evidence on their diurnal association
derived from frequent measurements of both variables is, however,
lacking in humans.
Methods We investigated the relationship between blood pressure levels
recorded by an ambulatory device and interstitial glucose concentrations
on an outpatient basis, in patients with normal glucose tolerance
(N=20), either normotensive (group A; N=10), or newly diagnosed with
essential hypertension (group B; N=10).
Results In the population throughout the 24-h monitoring period, there
was a significant positive correlation between interstitial glucose
concentrations and systolic, diastolic, and mean 24-h blood pressure
levels, which was retained in patients with hypertension compared with
normotensive patients. In patients with newly diagnosed hypertension,
interstitial glucose concentrations exhibit significant correlation to
systolic blood pressure levels during the 24-h period, but no
association with diastolic and mean blood pressure during the night,
whereas the reverse is the case in patients with normal glucose
tolerance and normal blood pressure.
Conclusion Diurnal variations of continuously monitored interstitial
glucose concentrations significantly associate with blood pressure
levels in both normotensive and hypertensive humans, indicating a common
pathway of circadian autoregulation, probably stemming from both central
mechanisms and peripheral inputs. Such a pathway might underlie similar
pathophysiological aberration in disease states such as the metabolic
syndrome. Blood Press Monit 13:309-317 (C) 2008 Wolters Kluwer Health
vertical bar Lippincott Williams & Wilkins.
ER -