TY - JOUR
TI - The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1,
IGFBP-2, and IGFBP-3 in the European Prospective Investigation into
Cancer and Nutrition
AU - Crowe, Francesca L.
AU - Key, Timothy J.
AU - Allen, Naomi E.
AU - Appleby,
AU - Paul N.
AU - Roddam, Andrew
AU - Overvad, Kim
AU - Gronbaek, Henning and
AU - Tjonneland, Anne
AU - Halkjaer, Jutte
AU - Dossus, Laure
AU - Boeing,
AU - Heiner
AU - Kroeger, Janine
AU - Trichopoulou, Antonia
AU - Dilis, Vardis
AU - and Trichopoulos, Dimitrios
AU - Boutron-Ruault, Marie-Christine
AU - De
AU - Lauzon, Blandine
AU - Clavel-Chapelon, Francoise
AU - Palli, Domenico and
AU - Berrino, Franco
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Sacerdote,
AU - Carlotta
AU - Bueno-de-Mesquita, H. Bas
AU - Vrieling, Alina
AU - van Gils,
AU - Carla H.
AU - Peeters, Petra H. M.
AU - Gram, Inger T.
AU - Skeie, Guri and
AU - Lund, Eiliv
AU - Rodriguez, Laudina
AU - Jakszyn, Paula
AU - Molina-Montes,
AU - Esther
AU - Tormo, Maria J.
AU - Barricarte, Aurelio
AU - Larranaga, Nerea
AU - and Khaw, Kay-Tee
AU - Bingham, Sheila
AU - Rinaldi, Sabina
AU - Slimani,
AU - Nadia
AU - Norat, Teresa
AU - Gallo, Valentina
AU - Riboli, Elio
AU - Kaaks,
AU - Rudolf
JO - Cancer Epidemiology, Biomarkers & Prevention
PY - 2009
VL - 18
TODO - 5
SP - 1333-1340
PB - AMER ASSOC CANCER RESEARCH
SN - 1055-9965, 1538-7755
TODO - 10.1158/1055-9965.EPI-08-0781
TODO - null
TODO - Circulating concentrations of insulin-like growth factor I (IGF-I) and
IGF binding proteins (IGFBP) have been associated with the risk of
several types of cancer. Dietary correlates of IGF-I and IGFBPs are not
yet well established. The objective of this study was to assess the
association between dietary intake and serum concentrations of IGF-I,
IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men
and women taking part in the European Prospective Investigation into
Cancer and Nutrition. Diet was assessed using country-specific validated
dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2
and IGFBP-3 were measured, and the associations between diet and IGF-I
and IGFBPs were assessed using multiple linear regression adjusting for
sex, age, body mass index, smoking status, and alcohol and energy
intake. Each I SD increment increase in total and dairy protein and
calcium intake was associated with an increase in IGF-I concentration of
2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a
decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for
all), respectively. There were no significant associations between the
intake of protein or calcium from nondairy sources and IGF-I. The
results from this large cross-sectional analysis show that either the
intake of dairy protein or calcium is an important dietary determinant
of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more
likely to be protein from dairy products. (Cancer Epidemiol Biomarkers
Prev 2009;18(5):1333-40)
ER -