TY - JOUR
TI - DNA variants, plasma levels and variability of Interleukin-6 in
myocardial infarction survivors: Results from the AIRGENE study
AU - Ljungman, Petter
AU - Bellander, Tom
AU - Nyberg, Fredrik
AU - Lampa, Erik
AU - and Jacquemin, Benedicte
AU - Kolz, Melanie
AU - Lanki, Timo and
AU - Mitropoulos, John
AU - Muller, Martina
AU - Picciotto, Sally
AU - Pistelli,
AU - Riccardo
AU - Rucker, Regina
AU - Koenig, Wolfgang
AU - Peters, Annette and
AU - AIRGENE Study Grp
JO - Thrombosis Research
PY - 2009
VL - 124
TODO - 1
SP - 57-64
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 0049-3848
TODO - 10.1016/j.thromres.2008.10.009
TODO - Inflammation; Genetics; IL-6; Myocardial infarction; Epidemiology
TODO - Introduction: Increased levels of interleukin 6 (IL-6), a marker for
systemic inflammation, have been associated with cardiovascular
morbidity and mortality.
Materials and Methods: We investigated the influence of IL6 gene
polymorphisms on mean level and variability of plasma IL-6 in a
population of myocardial infarction survivors recruited in six European
cities as part of the AIRGENE study. DNA from each individual was
collected and genotyped for eight functional and tagging single
nucleotide polymorphisms (SNPs) in the IL6 gene.
Results: We analyzed 946 subjects with 5520 repeated plasma samples for
IL-6 levels. For four IL6 SNPs in high linkage disequilibrium,
heterozygous and homozygous minor allele genotypes were associated with
an increase in mean plasma IL-6 levels. SNP rs1800795 was associated
with a 6.3% increase in IL-6 (95% confidence interval [CI]
1.7-11.2%) For these SNPs, we found that genotypes associated with
higher IL-6 levels also tended to be associated to higher
between-individual variability of IL-6 levels on the log-scale than
other genotypes. Variability over time within individuals varied little
by genotype.
Conclusions: We found four genetic polymorphisms in the IL6 gene
associated with mean level and variability of plasma IL-6 between
individuals in myocardial infarction survivors. (C) 2008 Elsevier Ltd.
All rights reserved.
ER -