TY - JOUR
TI - Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 Variations
Does Not Impact Alcohol Dependence Disorder Features
AU - Drago, Antonio
AU - Liappas, Ioannis
AU - Petio, Carmine
AU - Albani, Diego
AU - and Forloni, Gianluigi
AU - Malitas, Petros
AU - Piperi, Christina and
AU - Politis, Antonis
AU - Tzavellas, Elias O.
AU - Zisaki, Katerina K. and
AU - Prato, Francesca
AU - Batelli, Sara
AU - Polito, Letizia
AU - De Ronchi,
AU - Diana
AU - Paparrigopoulos, Thomas
AU - Kalofoutis, Anastasios and
AU - Serretti, Alessandro
JO - International Journal of Environmental Research and Public Health
PY - 2009
VL - 6
TODO - 7
SP - 1980-1990
PB - MDPI
SN - 1660-4601
TODO - 10.3390/ijerph6071980
TODO - gene; alcohol dependence; IL1A; IL1B; TNF; 5HTPR; HTR2A; TPH2;
association
TODO - We assessed a set of biological (HDL, LDL, SGOT, SGPT, GGT, HTc, Hb and
T levels) and psychometric variables (investigated through HAM-D, HAM-A,
GAS, Liebowitz Social Anxiety Scale, Mark & Mathews Scale, Leyton
scale, and Pilowski scale) in a sample of 64 alcohol dependent patients,
at baseline and after a detoxification treatment. Moreover, we recruited
47 non-consanguineous relatives who did not suffer alcohol related
disorders and underwent the same tests. In both groups we genotyped 11
genetic variations (rs1800587; rs3087258; rs1799724; 5-HTTLPR;
rs1386493; rs1386494; rs1487275; rs1843809; rs4570625; rs2129575;
rs6313) located in genes whose impact on alcohol related behaviors and
disorders has been hypothesized (IL1A, IL1B, TNF, 5-HTTLPR, TPH2 and
HTR2A). We analyzed the epistasis of these genetic variations upon the
biological and psychological dimensions in the cases and their
relatives. Further on, we analyzed the effects of the combined genetic
variations on the short - term detoxification treatment efficacy.
Finally, being the only not yet investigated variation within this
sample, we analyzed the impact of the rs6313 alone on baseline
assessment and treatment efficacy. We detected the following results:
the couple rs6313 + rs2129575 affected the Leyton - Trait at admission
(p = 0.01) (obsessive-compulsive trait), whilst rs1800587 + 5-HTTLPR
impacted the Pilowski test at admission (p = 0.01) (hypochondriac
symptoms). These results did not survive Bonferroni correction (p =
0.004). This lack of association may depend on the incomplete gene
coverage or on the small sample size which limited the power of the
study. On the other hand, it may reflect a substantial absence of
relevance of the genotype variants toward the alcohol related
investigated dimensions. Nonetheless, the marginal significance we
detected could witness an informative correlation worth investigating in
larger samples.
ER -