TY - JOUR
TI - Investigation of serum bactericidal activity in childhood and
adolescence 3-6 years after vaccination with a single dose of serogroup
C meningococcal conjugate vaccine
AU - Sakou, Irine-Ikbale
AU - Tzanakaki, Georgina
AU - Tsolia, Maria N. and
AU - Sioumala, Maria
AU - Barbouni, Anastasia
AU - Kyprianou, Miltiades and
AU - Papaevangelou, Vana
AU - Tsitsika, Artemis
AU - Blackwell, Caroline C. and
AU - Kafetzis, Dimitris
AU - Kremastinou, Jenny
JO - Vaccine
PY - 2009
VL - 27
TODO - 33
SP - 4408-4411
PB - Elsevier Sci Ltd, Exeter, United Kingdom
SN - 0264-410X
TODO - 10.1016/j.vaccine.2009.05.047
TODO - MenC vaccine; Bactericidal activity; Children; Adolescence
TODO - Serogroup C meningococcal conjugate vaccines were introduced in Greece
in 2001, and although no cases of serogroup C meningococcal disease were
recorded in 2004, a steady increase was observed since 2005. In this
study, serum bactericidal activity was assessed in sera of 269
vaccinated children at: a mean time of about 5 years after vaccination.
Non-protective antibody titers were observed in most children vaccinated
at age <6 years (85.9%), followed by those between 6 and 10 years
(62.2%). This percentage was considerably lower in adolescents
vaccinated at an age >10 years (37.8%) (p < 0.01). Geometric mean
concentrations of serum IgG antibodies against serogroup C showed a
similar variation. The results indicate that serum bactericidal antibody
titers significantly correlate with age of vaccination; most children do
not have protective antibody titers few years after immunization in
infancy and childhood whereas most adolescents maintain sustained
protection. (C) 2009 Elsevier Ltd. All rights reserved.
ER -