TY - JOUR
TI - Physical activity and risk of prostate cancer in the European
Prospective Investigation into Cancer and Nutrition (EPIC) cohort
AU - Johnsen, Nina Fans
AU - Tjonneland, Anne
AU - Thomsen, Birthe L. R. and
AU - Christensen, Jane
AU - Loft, Steffen
AU - Friedenreich, Christine
AU - Key,
AU - Timothy J.
AU - Allen, Naomi E.
AU - Lahmann, Petra H.
AU - Mejlvig, Lotte
AU - and Overvad, Kim
AU - Kaaks, Rudolf
AU - Rohrmann, Sabine
AU - Boing,
AU - Heiner
AU - Misirli, Gesthimani
AU - Trichopoulou, Antonia
AU - Zylis,
AU - Dimosthenis
AU - Tumino, Rosario
AU - Pala, Valeria
AU - Bueno-de-Mesquita,
AU - H. Bas
AU - Kiemeney, Lambertus A.
AU - Rodriguez Suarez, Laudina and
AU - Gonzalez, Carlos A.
AU - Sanchez, Maria-Jose
AU - Maria Huerta, Jose and
AU - Barricarte Gurrea, Aurelio
AU - Manjer, Jonas
AU - Wirfalt, Elisabet and
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Boffetta, Paolo
AU - Egevad, Lars and
AU - Rinaldi, Sabina
AU - Riboli, Elio
JO - International Journal  of Cancer
PY - 2009
VL - 125
TODO - 4
SP - 902-908
PB - Wiley
SN - 0020-7136
TODO - 10.1002/ijc.24326
TODO - physical activity; exercise; prostate cancer; cohort
TODO - The evidence concerning the possible association between physical
activity and the risk of prostate cancer is inconsistent and additional
data are needed. We examined the association between risk of prostate
cancer and physical activity at work and in leisure time in the European
Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In
our study, including 127,923 men aged 20-97 years from 8 European
countries, 2,458 cases of prostate cancer were identified during 8.5
years of followup. Using the Cox proportional hazards model, we
investigated the associations between prostate cancer incidence rate and
occupational activity and leisure time activity in terms of
participation in sports, cycling, walking and gardening; a metabolic
equivalent (MET) score based on weekly time spent on the 4 activities;
and a physical activity index. MET hours per week of leisure time
activity, higher score in the physical activity index, participation in
any of the 4 leisure time activities, and the number of leisure time
activities in which the participants were active were not associated
with prostate cancer incidence. However, higher level of occupational
physical activity was associated with lower risk of advanced stage
prostate cancer (p(trend) = 0.024). In conclusion, our data support the
hypothesis of an inverse association between advanced prostate cancer
risk and occupational physical activity, but we found no support for an
association between prostate cancer risk and leisure time physical
activity. (C) 2009 UICC
ER -