TY - JOUR
TI - Treatment of Sperm With Platelet-activating Factor Does Not Improve
Intrauterine Insemination Outcome in Unselected Cases of Mild Male
Factor Infertility: A Prospective Double-blind Randomized Crossover
Study
AU - Baka, Stavroula
AU - Grigoriou, Odysseas
AU - Hassiakos, Dirnitris and
AU - Konidaris, Socrates
AU - Papadias, Konstantinos
AU - Makrakis, Evangelos
JO - European urology oncology
PY - 2009
VL - 74
TODO - 5
SP - 1025-1028
PB - EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
SN - null
TODO - 10.1016/j.urology.2009.06.023
TODO - null
TODO - OBJECTIVES To evaluate the effect of sperm treatment with exogenous
platelet-activating factor (PAF) on intrauterine insemination (IUI)
clinical pregnancy rate in cases of mild male factor infertility. PAF is
a phospholipid mediator, which is present in human sperm.
METHODS The study was performed in the Assisted Reproduction Unit of the
2nd Department of Obstetrics and Gynecology, University of Athens,
Aretaieion Hospital, Athens, Greece, and included 92 couples who
presented with mild male factor infertility-all candidates for IUI. A
maximum of 4 IUI cycles per couple with or without exogenous PAF
treatment were performed and the main outcome measure was the clinical
pregnancy rate (pregnancies confirmed by ultrasonography per 100
cycles).
RESULTS The overall clinical pregnancy rate after a maximum of 4 IUI
cycles was comparable in cases with and without sperm treatment with PAF
(12.24% vs 11-11%). Addition or exclusion of PAF sperm treatment in
the same patients did not significantly alter the outcome.
CONCLUSIONS The generalized use of exogenous PAF for the preparation of
sperm in unselected cases of mild male infertility does not improve the
clinical outcome of IUI. UROLCGY 74: 1025-1028, 2009. (C) 2009 Elsevier
Inc.
ER -